趋化因子受体6在结直肠癌肝转移灶与原发性肝癌中的表达差异比较  

Comparison of expression of chemokine receptor 6 expression in colorectal cancer liver metastases and primary liver cancer

作　　者：韦成江 刘义[1] 梁立盛 陆惠军 朱亚珍 赖浩[1] 莫显伟[1] 龚晗 冯雁[1] 林源[1] Wei Chengjiang;Liu Yi;Liang Lisheng;Lu Huijun;Zhu Yazhen;Lai Hao;Mo Xianwei;Gong Han;Feng Yan;Lin Yuan(The Second Ward of Gastrointestinal Surgery,Guangxi Medical University Affiliated Tumor Hospital,Nanning 530021,China)

机构地区：[1]广西医科大学附属肿瘤医院胃肠外科二病区,南宁530021

出　　处：《广西医科大学学报》2020年第6期1113-1118,共6页Journal of Guangxi Medical University

基　　金：广西科技计划重点研发资助项目(No.AB18221086;No.AB16380202)。

摘　　要：目的:对比检测趋化因子受体6(CCR6)在结直肠癌原发灶、肝转移灶、原发性肝癌和正常肝组织中的表达差异,探讨CCR6在结直肠癌肝转移中的可能作用。方法:收集2013年1月至2018年10月于广西医科大学附属肿瘤医院就诊的35例结直肠癌并肝转移患者,及同期就诊的35例原发性肝癌患者的手术切除组织样本,共收集结直肠癌肝转移灶35例,配对原发灶27例,远癌(距原发灶>5 cm)正常肠黏膜组织27例;原发性肝癌组织35例;远癌(距肿瘤>1 cm)正常肝组织35例。通过免疫组织化学方法检测CCR6在组织中的表达情况。结果:结直肠癌肝转移患者的原发灶CCR6高表达率高于远癌正常肠黏膜组织(P<0.05)。结直肠癌肝转移灶与原发性肝癌组织CCR6高表达率均高于远癌正常肝组织(P<0.05)。转移性肝癌与原发性肝癌的CCR6高表达率比较,差异无统计学意义(P>0.05)。结论:CCR6在原发性肝癌和结直肠肝转移中均为高表达,提示其参与了肝脏肿瘤的形成与生长。CCR6高表达可能促进结直肠癌发生肝转移。Objective:To compare the differences of chemokine receptor 6(CCR6)expression in primary colorectal cancer,liver metastases,primary liver cancer,and normal liver tissues,so as to explore the possible effects of CCR6 in colorectal cancer liver metastases.Methods:Collected surgical tissuesamples from 35 patients with liver metastases of colorectal cancer and35 patients with primary liver cancerwho were treated in Guangxi Medical University Affiliated Tumor Hospital from January 2013 to October 2018.Atotalof 35 cases of colorectal cancer with liver metastases mate with 27 cases of primary foci and 27 cases of normal intestinal mucosa tissues distant from cancer(>5 cm from the primary foci),as well as 35 cases of primary liver cancer tissues and 35 cases of normal liver tissues distant from cancer(>1 cm from the tumor)were collected.The expression of CCR6 in tissues was detected by immunohistochemistry.Results:The expression of CCR6 in patients with liver metastases of colorectal cancerat the primaryfoci was higher than that in normal intestinal mucosa tissues distant from cancer(P<0.05).The expression of CCR6 in colorectal cancer liver metastases and primary liver cancer tissues were higher than those in normal liver tissues distant from cancer(P<0.05).There was no statistically significant difference in the expression of CCR6 between metastatic liver cancer and primary liver cancer(P>0.05).Conclusion:CCR6 is highly expressed in primary liver cancer and liver metastasis of colorectal cancer,suggesting that it is involved in the formation and growth of liver tumors.High expression of CCR6 may promote liver metastasis of colorectal cancer.

关 键 词：结直肠癌肝转移 原发性肝癌 CCR6 

分 类 号：R735.34[医药卫生—肿瘤]