铝与阿尔茨海默病发生间关系的研究进展  

Research Progress on the Relationship between Aluminum and Alzheimer′s Disease

作　　者：孟雪莲[1] 苏书杰 冯琳琳 陈长兰[1] MENG Xue-lian;SU Shu-jie;FENG Lin-lin;CHEN Chang-lan(School of Pharmaceutical Science,Liaoning University,Shenyang,110036,China)

机构地区：[1]辽宁大学药学院,辽宁沈阳110036

出　　处：《辽宁大学学报（自然科学版）》2020年第2期156-166,共11页Journal of Liaoning University：Natural Sciences Edition

基　　金：国家自然科学基金面上项目(31371085);辽宁大学本科教学改革研究项目(HG2013YA0024);辽宁省天然产物制药工程技术研究中心资助项目。

摘　　要：近年来随着免疫铝佐剂与蛋白及多肽作用机制研究的不断深入,铝与AD发生之间的关系研究重新引起人们的重视.研究发现三价铝离子Al^3+对Aβ多肽及磷酸化Tau蛋白具有非常强的结合能力,Al^3+作为交联剂具有促进Aβ多肽及磷酸化Tau蛋白聚集等作用,铝在AD的发生过程中具重要作用.通过控制铝摄入防治AD的发生具有重要理论和临床意义.In recent years,with the deepening of the research on the mechanism of interaction between immune aluminum adjuvants andproteins,polypeptides,the researches on the relationship between the occurrence of Alzheimer′s disease(AD)and aluminum has attracted new attention.Studies have found that Al^3+ has very strong binding ability to A beta polypeptides and phosphorylated Tau proteins.As A crosslinking agent,Al^3+ can promote the aggregation of A beta polypeptides and phosphorylated Tau proteins,and aluminum plays an important role in the occurrence of AD.The prevention and treatment of AD by controlling aluminum intake has important theoretical and clinical significance.

关 键 词：铝 AD Aβ多肽 TAU蛋白 

分 类 号：R967[医药卫生—药理学]