智能响应性19F磁共振纳米分子成像探针诊断肿瘤研究进展  

Research progresses of smart responsive 19F magnetic resonance nanomolecular imaging probes in diagnosis of tumors

作　　者：刘爽[1,2] 孙夕林[1,2] 王凯[1,2] 吴丽娜[1,2] LIU Shuang;SUN Xilin;WANG Kai;WU Lina(TOF-PET/CT/MR Center,the Fourth Hospital of Harbin Medical University,Harbin 150028,China;Molecular Imaging Research Center,Harbin Medical University,Harbin 150028,China)

机构地区：[1]哈尔滨医科大学附属第四医院TOF-PET/CT/MR中心,黑龙江哈尔滨150028 [2]哈尔滨医科大学分子影像研究中心,黑龙江哈尔滨150028

出　　处：《中国医学影像技术》2020年第6期940-944,共5页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金(81771903、81627901);国家重点基础研究发展计划(2015CB931800);黑龙江省自然科学基金委留学归国科学基金(LC2016034);哈尔滨医科大学附属第四医院杰出青年基金(HYDSYJQ201601)。

摘　　要：智能响应性纳米分子探针可在精确成像监测探针分布并定位肿瘤的前提下实现肿瘤靶向成像、快速响应、灵敏诊断及精确治疗。MRI,特别是19F-MRI灵敏度高和背景噪声低,近年来采用智能响应性19F-MR纳米分子成像探针检测pH变化以及酶活性、还原微环境、乏氧和光热等方面的研究不断深入。本文围绕智能响应性19F-MR纳米分子成像探针诊断肿瘤的研究进展进行综述。Using smart responsive nanomolecular probes can realize tumor targeted imaging with rapid response,sensitive diagnosis and precise treatment under the guidance of imaging on detection of probe distributions and localization of tumors.MRI,especially 19F-MRI,has high sensitivity and low background noise.In recent years,smart responsive 19F-MR nanomolecular imaging probes had been applied for detecting changes of pH,enzyme activity,reducing microenvironment,hypoxia,light and thermo-responsive aspects.The research progresses of smart responsive 19F magnetic resonance nanomolecular imaging probes in diagnosis of tumors were reviewed in this article.

关 键 词：磁共振成像 分子成像 分子探针技术 智能响应 

分 类 号：R73[医药卫生—肿瘤] R445.2[医药卫生—临床医学]