肠内营养乳剂对呼吸机支持治疗呼吸衰竭患者营养及免疫指标的影响  

Effects of enteral nutrition emulsion support on nutrition and immune indexes in respiratory failure patients undergoing ventilator support

作　　者：万有军 陈祥 魏继红 WAN You-jun;CHEN Xiang;WEI Ji-hong(Department of Emergency,Xuancheng People s Hospital,Xuancheng 242000,Anhui,China;Department of Critical Medicine,Xuancheng People s Hospital,Xuancheng 242000,Anhui,China)

机构地区：[1]宣城市人民医院急诊科,安徽宣城242000 [2]宣城市人民医院重症医学科,安徽宣城242000

出　　处：《川北医学院学报》2020年第3期509-512,共4页Journal of North Sichuan Medical College

摘　　要：目的:探讨肠内营养乳剂对呼吸机支持治疗呼吸衰竭患者营养及免疫指标的影响。方法:采用随机数表法,将102例采用呼吸机支持治疗的呼吸衰竭患者分为观察组和对照组,每组各51例。对照组给予常规肠外营养支持治疗,观察组给予肠内营养乳剂支持治疗,均治疗2周。检测患者治疗前后的血清总蛋白、血清白蛋白、前白蛋白、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、pH值、血氧分压(PaO 2)及血二氧化碳分压(PaCO 2)水平,观察两组治疗期间并发症发生情况。结果:治疗后,观察组的血清总蛋白、血清白蛋白、前白蛋白、IgA、IgG、pH及PaO 2指标明显高于治疗前及对照组(P<0.05),而PaCO 2明显低于治疗前及对照组(P<0.05)。治疗期间,观察组高血糖发生率为0.00%,明显低于对照组的7.84%(P<0.05);但两组肝肾功能损害、泌尿系统感染及吸入性肺炎的并发症发生率比较,差异无统计学意义(P>0.05)。结论:肠内营养乳剂支持能明显改善呼吸机支持治疗呼吸衰竭患者的营养状态及免疫功能,临床效果较好。Objective:To explore effects of enteral nutrition emulsion support on nutrition and immune indexes in respiratory failure patients undergoing ventilator support.Methods:A total of 102 respiratory failure patients who needed ventilator support were enrolled.They were divided into observation group and control group by random number table method,51 cases in each group.The control group was treated with routine parenteral nutrition support,while observation group was treated with enteral nutrition emulsion support,all patients were treated for 2 weeks.Before and after treatment,levels of serum total protein,serum albumin,prealbumin,immunoglobulin A(IgA),immunoglobulin M(IgM),pH value,partial pressure of oxygen(PaO2)and partial pressure of carbon dioxide(PaCO 2)were measured.The occurrence of complications in both groups during treatment was observed.Results:After treatment,serum total protein,serum albumin,prealbumin,IgA,IgG,pH and PaO 2 in observation group were significantly higher than those before treatment and in control group(P<0.05),while PaCO 2 was significantly lower than that before treatment and in control group(P<0.05).During treatment,incidence of hyperglycemia in observation group was significantly lower than that in control group(0.00%vs.7.84%)(P<0.05).However,there was no significant difference in incidence of liver-kidney function impairment,urinary system infection or aspiration pneumonia between the two groups(P>0.05).Conclusion:Enteral nutrition emulsion support can significantly improve nutritional status and immune function of respiratory failure patients undergoing ventilator support,with relatively better clinical effect.

关 键 词：呼吸衰竭 呼吸机支持治疗 肠内营养乳剂 肠道营养 免疫功能 

分 类 号：R735.7[医药卫生—肿瘤]