Additive manufacturing in radiation oncology:a review of clinical practice,emerging trends and research opportunities  

作　　者：Rance Tino Martin Leary Adam Yeo Elizabeth Kyriakou Tomas Kron Milan Brandt 

机构地区：[1]RMIT Centre for Additive Manufacture,School of Engineering,RMIT University,Melbourne,Australia [2]Physical Sciences Department,Peter MacCallum Cancer Centre,Melbourne,Australia [3]ARC Industrial Transformation Training Centre in Additive Biomanufacturing,Queensland University of Technology,Brisbane,Australia [4]Centre for Medical Radiation Physics,University of Wollongong,Wollongong Australia

出　　处：《International Journal of Extreme Manufacturing》2020年第1期47-66,共20页极端制造（英文）

基　　金：This research was conducted by the Australian Research Council Industrial Transformation Training Centre in Additive Biomanufacturing(IC160100026).The support of the Gross Foundation is also acknowledged.

摘　　要：The additive manufacturing(AM)process plays an important role in enabling cross-disciplinary research in engineering and personalised medicine.Commercially available clinical tools currently utilised in radiotherapy are typically based on traditional manufacturing processes,often leading to non-conformal geometries,time-consuming manufacturing process and high costs.An emerging application explores the design and development of patient-specific clinical tools using AM to optimise treatment outcomes among cancer patients receiving radiation therapy.In this review,we:•highlight the key advantages of AM in radiotherapy where rapid prototyping allows for patient-specific manufacture•explore common clinical workflows involving radiotherapy tools such as bolus,compensators,anthropomorphic phantoms,immobilisers,and brachytherapy moulds;and•investigate how current AM processes are exploited by researchers to achieve patient tissuelike imaging and dose attenuations.Finally,significant AM research opportunities in this space are highlighted for their future advancements in radiotherapy for diagnostic and clinical research applications.

关 键 词：additive manufacturing radiotherapy tools DOSIMETRY EBRT PATIENT-SPECIFIC cancer treatment quality assurance 

分 类 号：R730.55[医药卫生—肿瘤]