多系统萎缩患者非运动症状临床研究进展  

Clinical diagnosis and treatment of non-motor symptoms of multiple system atrophy

作　　者：王雪梅[1,2] 刘疏影[1] 陈彪[1] Wang Xuemei;Liu Shuying;Chan Piu(Department of Neurology,Xuanwu Hospital of Capital Medical University,National Clinical Research Center for Geriatric Disorders,Beijing 100053,China;Department of Neurology,Beijing Luhe Hospital of Capital Medical University,Beijing 101149,China)

机构地区：[1]首都医科大学宣武医院神经内科,国家老年疾病临床医学研究中心,北京100053 [2]首都医科大学附属北京潞河医院神经内科,101149

出　　处：《中华神经科杂志》2020年第6期460-464,共5页Chinese Journal of Neurology

基　　金：国家重点研发计划资助项目(2018YFC1312001,2017YFC0840105,2017ZX09304018);北京市医院管理局"使命"计划专项经费资助项目(SML20150803);北京市科学技术委员会资助项目(Z171100000117013)。

摘　　要：多系统萎缩是一种成年隐匿起病、散发性、进展相对较快的神经系统退行性疾病,其非运动症状如排尿障碍、性功能减退、血压变异、呼吸、睡眠及情绪障碍等,可出现于运动症状前数年,且随病程持续进展,严重影响患者的生活质量。多系统萎缩非运动症状多样而复杂,早期正确识别对优化治疗策略、综合管理至关重要。文中就其近年来多系统萎缩非运动症状的相关研究进展进行综述,旨在提高临床医师对多系统萎缩的诊断水平,以指导治疗,改善患者的生活质量。Multiple system atrophy(MSA)is a sporadic neurodegenerative disease with insidious onset,and relatively rapid progress in adult.MSA patients may be admitted to different departments of hospital several years before the full manifestation of motor symptoms,because of various non-motor symptoms such as urinary disorders,sexual dysfunction,orthostatic hypotension,psychic symptoms and sleep disorders.This may delay the diagnosis and treatment of MSA.The review is to improve the understanding of the non-motor symptoms of MSA,which may help to reach more accurate diagnosis and better treatment,and improve the quality of life of patients with MSA.

关 键 词：多系统萎缩 非运动症状 诊断 临床研究 

分 类 号：R741[医药卫生—神经病学与精神病学]