三七通舒胶囊联合依达拉奉治疗急性脑梗死的效果及对患者神经功能、脑血管储备能力的影响  

Effects of sanqi tongshu capsule combined with edaravone on acute cerebral infarction and its influence on neurological function and cerebrovascular reserve capacity

作　　者：雷小娟[1] 杨国东[2] 程相杰[2] Lei Xiaojuan;Yang Guodong;Cheng Xiangjie(Department of Chinese Medicine,Nanyang Second People’s Hospital,Nanyang 473000,China;Department of Internal Medicine-Neurology,Nanyang Second People’s Hospital,Nanyang,473000,China)

机构地区：[1]河南省南阳市第二人民医院中药科,473000 [2]河南省南阳市第二人民医院神经内科,473000

出　　处：《中国实用医刊》2020年第6期114-117,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨三七通舒胶囊联合依达拉奉治疗急性脑梗死的效果及对患者神经功能、脑血管储备能力的影响。方法将2017年6月至2018年12月南阳市第二人民医院收治的82例急性脑梗死患者随机均分为研究组(采用三七通舒胶囊联合依达拉奉治疗,41例)和对照组(采用依达拉奉治疗,41例)。比较两组治疗15 d后的治疗效果和两组治疗前及治疗15 d后神经功能[美国国立卫生院卒中量表评分(NIHSS评分)]、脑血管储备能力[平均流速(Vm)、脉动指数(PI)、脑血管阻力(CVR)]、炎性因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)]、疾病相关因子[C-X-C配体4(CXCL-4)、C-X-C配体12(CXCL-12)]水平。结果治疗15 d后,两组显效率比较差异未见统计学意义(P>0.05)。治疗15 d后,两组患者NIHSS评分水平、PI水平、炎性因子(IL-6、TNF-α、CRP)水平、疾病相关因子(CXCL-4、CXCL-12)水平均较治疗前下降,且研究组上述指标水平低于对照组(P<0.05);两组患者Vm、CVR水平均较治疗前上升,且研究组上述指标水平高于对照组(P<0.05)。结论三七通舒胶囊联合依达拉奉治疗急性脑梗死效果显著,能够有效改善神经功能及脑血管储备能力,降低机体炎性反应。Objective To study the effects of sanqi tongshu capsule combined with edaravone on acute cerebral infarction and its influence on neurological function and cerebrovascular reserve capacity.Methods Eighty-two patients with acute cerebral infarction in Nanyang Second People’s Hospital from June 2017 to December 2018 were randomly and evenly divided into study group(treated with sanqi tongshu capsule combined with edaravone,41 cases)and control group(treated with edaravone,41 cases).The therapeutic effects after 15 days of treatment between the two groups were compared.The neurological function[national institutes of health stroke scale score(NIHSS score)],cerebrovascular reserve capacity[mean velocity(Vm),pulsation index(PI),cerebrovascular resistance(CVR)],inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)]and disease-related factors[C-X-C ligand 4(CXCL-4),C-X-C ligand 12(CXCL-12)]between the two groups were compared before treatment and after 15 days of treatment.Results After 15 days of treatment,there was no significant difference in the marked effective rate between the two groups(P>0.05).After 15 days of treatment,the NIHSS score,PI and levels of inflammatory factors(IL-6,TNF-α,CRP)and disease-related factors(CXCL-4,CXCL-12)in the two groups were significantly decreased compared with those before treatment,and the indexes in study group were significantly lower than those in control group(P<0.05).The levels of Vm and CVR in the two groups were significantly increased compared with those before treatment,and the levels in study group were significantly higher than those in control group(P<0.05).Conclusions Sanqi tongshu capsule combined with edaravone has significant effects in the treatment of acute cerebral infarction,and it can effectively improve neurological function and cerebrovascular reserve capacity,and reduce the body’s inflammatory response.

关 键 词：脑梗死 急性 依达拉奉 三七通舒胶囊 

分 类 号：R74[医药卫生—神经病学与精神病学]