(±)-6-3’a,7-6’-Isowallichilide:A pair of enantiomeric phthalide dimers from Ligusticum chuanxiong with new 6-3’a,7-6’ dimerization sites  

作　　者：Xin Fang Qiang Ma Yi Feng Shuang Liang 

机构地区：[1]Innovation Research Institute of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China

出　　处：《Chinese Chemical Letters》2020年第5期1251-1253,共3页中国化学快报（英文版）

基　　金：supported by the Shanghai Municipal Commission of Health and Family Planning(No.ZY3-CCCX-3-5001);the Science and Technology Commission of Shanghai Municipality(Nos.14401901400,15DZ2292000);the Expenditure Budget Program of Shanghai Municipal Education Commission(No.2016YSN24);Xinglin Young Talent Program of Shanghai University of Traditional Chinese Medicine。

摘　　要：(+)-6-3’a,7-6’-Isowallichilide and(-)-6-3’a,7-6’-isowallichilide,a pair of enantio meric phthalide dimers featuring new 6-3’a,7-6’dimerization sites,were isolated from Ligusticum chuanxiong.The structures were elucidated by NMR spectroscopy and X-ray diffraction analysis.Furthermore,the absolute configurations were assigned using experimental and theoretical electronic circular dichroism methods.Their nitric oxide inhibition,antiplatelet aggregation and antioxidant activities were investigated.

关 键 词：Ligusticum chuanxiong Phthalide dimers ENANTIOMERS Dimerization sites 

分 类 号：R284.3[医药卫生—中药学]