Diastereoselective synthesis of functionalized tetrahydro-γ-carbolines via a[3+3] cycloaddition of 2,2’-diester aziridines with β-(indol-2-yl)-α,β-unsaturated ketones  

作　　者：Xuejie Zou Yangzi Liu Shaojing Shang Wulin Yang Weiping Deng 

机构地区：[1]Shanghai Key Laboratory of New Drug Design and School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China

出　　处：《Chinese Chemical Letters》2020年第5期1293-1296,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.21772038);the China Postdoctoral Science Foundation(No.2018M632037)。

摘　　要：A Sc(OTf)3-catalyzed[3+3]cycloaddition of 2,2’-diester aziridines withβ-(indol-2-yl)-α,β-unsaturated ketones was developed,affording polysubstituted tetrahydro-y-carbolines in single diastereoisomers in good to excellent yields.

关 键 词：AZIRIDINE Tetrahydro-γ-carboline [3+3]cycloaddition Sc(OTf)3 DIASTEREOSELECTIVITY 

分 类 号：O626[理学—有机化学]