Diastereoselective 2,3-diazidation of indoles via copper(Ⅱ)-catalyzed dearomatization  

作　　者：Jiang Liu Zhongjin Fang Xin Liu Yandong Dou Jianze Jiang Fangfang Zhang Jiaojiao Qu Qing Zhu 

机构地区：[1]Key Laboratory of Bioorganic Synthesis of Zhejiang Province,College of Biotechnology and Bioengineering,Zhejiang University of Technology,Hangzhou 310014,China [2]Zhejiang Zhong Cheng Medicine Co.,Ltd.,Hangzhou 310012,China

出　　处：《Chinese Chemical Letters》2020年第5期1332-1336,共5页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(Nos.21472172,21272212);Natural Science Foundation of Zhejiang Province(No.LY17B060009)。

摘　　要：The copper-catalyzed directed dearomatization of indoles with the assistance of directing groups has been developed for the synthesis of 2,3-diazido indolines with good yields and excellent diastereoselectivities in aqueous solution.The resultant 2,3-diazides can be smoothly converted to other functional groups,including vicinal diamines,triazoles and benzotriazoles,in a single step.

关 键 词：Indole DIASTEREOSELECTIVE DEAROMATIZATION 2 3-Diazidation INDOLINE 

分 类 号：O626[理学—有机化学]