NF-κB家族成员RelA的翻译后修饰及其生理病理作用的研究进展  

Research progress on post-translational modification of NF-κB family member RelA and its physiological and pathological effects

作　　者：耿云峰 杜鸿斌 刘琳琳[1] 孙梦莹 鞠吉雨[3] 张杰彪 赵春玲[1] 田春艳 GENG Yun-Feng;DU Hong-Bin;LIU Lin-Lin;SUN Meng-Ying;JU Ji-Yu;ZHANG Jie-Biao;ZHAO Chun-Ling;TIAN Chun-Yan(Key Laboratory of Biopharmaceutics in Universities of Shandong Province,Weifang Medical University,Weifang 261053,China; Institute of Life Science,Military Medical Research Institute,Academy of Military Sciences,Beijing 100850,China; Key Laboratory of Immunology in Universities of Shandong Province,Weifang Medical University,Weifang 261053,China)

机构地区：[1]潍坊医学院山东省高校生物药物重点实验室,潍坊261053 [2]军事科学院军事医学研究院生命组学研究所,北京100850 [3]潍坊医学院山东省高校免疫学重点实验室,潍坊261053

出　　处：《生命科学》2020年第5期431-438,共8页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(31771563,81572578);山东省自然科学基金项目(ZR2018MH014,ZR2015HM028);潍坊医学院大学生科技创新基金项目(KX2018005)。

摘　　要：真核细胞转录因子NF-κB通过调节多种靶基因表达,参与炎症、免疫反应、程序性细胞死亡、细胞增殖和分化的调控。RelA是NF-κB家族一个重要的成员,其翻译后修饰可精准调控NF-κB的转录活性,在调节炎症、肿瘤、代谢以及免疫应答等重要的生命活动及相关疾病的发生发展过程中起重要作用。现总结相关领域最新研究进展,综述RelA翻译后修饰的种类、调控机制,对NF-κB通路功能的影响,及其在NF-κB介导的炎症、癌症等多种疾病中的功能。The eukaryotic transcription factor NF-κB is involved in the regulation of inflammation, immune response, programmed cell death, cell proliferation and differentiation by regulating the expression of multiple target genes. RelA is one of the most important members of the NF-κB family. Its post-translational modification can precisely regulate the transcriptional activation of NF-κB, and plays an important role in inflammation, tumor, metabolism, immune, and the occurrence and development of related diseases. In this review, we summarized the types, regulatory mechanisms, effects of post-translational modifications of RelA, and discussed its functions in various diseases such as NF-κB-mediated inflammation and cancer.

关 键 词：NF-ΚB 翻译后修饰 RELA 磷酸化 乙酰化 甲基化 

分 类 号：Q51[生物学—生物化学]