RELA

作品数:127被引量:427H指数:11
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RelA/p65磷酸化:驱动癌症进展的关键修饰
《生命的化学》2025年第3期381-393,共13页曹硕 孙许涛 吴思雨 毛彩云 宋运佳 
国家自然科学基金项目(82205056);黑龙江省自然科学基金优秀青年基金项目(YQ2022H020)。
p65磷酸化是NF-κB信号通路的重要调控机制,广泛参与了细胞增殖、凋亡、炎症和免疫应答等多种生理病理的调控。p65磷酸化能够诱导多种与癌症相关的基因表达,同时通过影响细胞存活与凋亡来影响癌症的进展。在癌症中,NF-κB通路通常异常激...
关键词:RelA/p65 磷酸化 癌症 NF-ΚB 
Climate-relevant gases and their impact on the climate and environment of polar oceans
《Advances in Polar Science》2025年第1期5-17,共13页ZHAN Liyang YE Wangwang YAN Jinpei ZHANG Miming LIU Jian TIAN Rong WANG Shanshan JIE Xiaomeng LI Yuhang WANG Wentao 
supported the National Natural Science Foundation of China(Grant nos.4227624,42376239 and 42476253)。
Because of their effect on climate,carbon dioxide(CO_(2)),methane(CH_(4)),nitrous oxide(N_(2)O),and dimethylsulfide(DMS)are collectively designated as climate-relevant gases(CRGs).CO_(2),CH_(4),and N_(2)O are greenhou...
关键词:POLAR ocean Arctic Ocean Southern Ocean climate-relavent gases greenhouse gases 
Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report
《World Journal of Clinical Cases》2025年第1期48-55,共8页Xiao-Yu Zhao Juan-Han Yu Yi-Hua Wang Yi-Xin Liu Lu Xu Lin Fu Ning Yi 
BACKGROUND Ependymoma with lipomatous differentiation is a rare type of ependymoma.The ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of centr...
关键词:EPENDYMOMA Lipomatous Molecular classification SUPRATENTORIAL ZFTA:RELA fusion Case report 
颠覆性指数测度有效性评估及其影响因素研究
《情报杂志》2024年第12期170-177,共8页李楠 任颖 张永娟 
[研究目的]颠覆性指数的提出为量化分析科学研究的创新性提供了新的视角和方法,探究颠覆性指数及其改进方法的有效性和影响因素有助于研究人员深层理解并合理运用相关定量计算方法,并为其今后的算法改进与拓展应用提出参考建议。[研究方...
关键词:颠覆性指数 有效性评估 同行评议 D指数 Dn指数 Rela_DZ指数 DT指数 
自体富血小板血浆对骨关节炎患者LXA4和p65-RelA的影响
《国际医药卫生导报》2024年第22期3764-3769,共6页常宝生 刘治桓 赵程锦 
国家自然科学基金(82160431)。
目的研究自体富血小板血浆(PRP)在骨关节炎(OA)患者中的临床效果,以及对患者脂氧素A4(LXA4)、核因子蛋白p65(p65-RelA)的影响。方法选取延安大学附属医院2022年10月至2023年4月收治的早、中期OA患者157例为研究对象,根据治疗方法分为两...
关键词:骨关节炎 富血小板血浆 脂氧素A4 核因子蛋白p65 临床效果 
A positive feedback loop between PLD1 and NF-κB signaling promotes tumorigenesis of nasopharyngeal carcinoma
《Journal of Genetics and Genomics》2024年第10期997-1006,共10页Ya-Qing Zhou Xi-Xi Cheng Shuai He Shu-Qiang Liu Yi-Qi Li Pan-Pan Wei Chun-Ling Luo Jin-Xin Bei 
This work was supported by the Guangdong Basic and Applied Basic Research Foundation(2024A1515013061);the Sci-Tech Project Foundation of Guangzhou City(2023A04J2141);National Natural Science Foundation(82261160657);Chang Jiang Scholars Program(J.-X.B.);Special Support Program of Guangdong(J.-X.B.)。
Phospholipase D(PLD)lipid-signaling enzyme superfamily has been widely implicated in various human malignancies,but its role and underlying mechanism remain unclear in nasopharyngeal carcinoma(NPC).Here,we analyze the...
关键词:PLD1 NF-κB pathway RELA Nasopharyngeal carcinoma(NPC) TUMORIGENESIS Positive feedback loop 
Ziwan-Taoren herb pair can exert an therapeutical effect in primary Sjogren’s syndrome through inhibiting the TLR/NF-κB pathway
《Traditional Medicine Research》2024年第8期11-22,共12页Kuok-Tong Lei Yun-Xia Wu Yun Lu Zi-Shan Wang Thi-Huong Nguyen Qiu-Ying Cai Wen Zhu Yue Wang 
grants from the National Natural Science Foundation of China(82274454).
Background:Ziwan and Taoren(ZT)is a classic medicine pair in the formula of Mai Dong Di Shao Decoction,has been used to treat primary Sjogren’s syndrome(pSS)for more than 20 years.But its action mechanism is still un...
关键词:traditional Chinese medicine primary Sjogren’s syndrome NF-κB RELA 
Aszonapyrone A Isolated from Neosartorya spinosa IFM 47025 Inhibits the NF-κB Signaling Pathway Activated by Expression of the Ependymoma-Causing Fusion Protein ZFTA-RELA
《Advances in Microbiology》2024年第9期448-467,共20页Kazuki Ishikawa Nao Kamiya Masaki Ishii Takashi Yaguchi Koji Ichinose Shinya Ohata 
Ependymoma is a rare and chemotherapy-resistant brain tumor, which has resulted in a delay in the development of drugs to treat it. A subclass of supratentorial ependymomas (ST-EPN), designated ST-EPN-zinc finger-tran...
关键词:Aszonapyrone A Neosartorya spinosa NF-κB Signaling Pathway EPENDYMOMA ZFTA-RELA 
Foodborne toxin Aflatoxin B_(1)induced glomerular podocyte inflammation through proteolysis of RelA,downregulation of miR-9 and CXCR4/TXNIP/NLRP3 pathway
《Food Science and Human Wellness》2024年第4期2289-2309,共21页Jie Zhang Shuang Yang Baocai Xu Zihui Qin Xinyi Guo Ben Wei Qinghua Wu Kamil Kuca Tushuai Li Wenda Wu 
funded by Suzhou Science and Technology Council(SNG201907);Universities Natural Science Foundation of Jiangsu Province(20KJB330002);General Program of China Postdoctoral Science Foundation(2022M711369);the Startup Funding of Soochow University,Jiangsu Province-Suzhou Science and Technology Planning Project(SL T201917);National Natural Science Foundation of China(32172922,31972741);Natural Science Foundation of Jiangsu Province of China(BK20211216,BK20221091);the Startup Funding of Hefei University of Technology(1302003712022058);China-CEEC Joint University Education Project(202010);the Excellence Project PrF UHK(2217/2022-2023)。
Aflatoxin B_(1)(AFB_(1))is a naturally-occurring mycotoxin and recognized as the most toxic foodborne toxin,particularly causing damages to kidney.Glomerular podocytes are terminally differentiated epithelial cells.AF...
关键词:Aflatoxin B_(1) Podocyte inflammation miRNA-9 Chemokine(C-X-C motif)receptor 4 RelA ubiquitin-dependent degradation 
芪地糖肾方对糖尿病肾病足细胞焦亡及MAPK14/RELA/Caspase-8信号通路的影响被引量:9
《中国实验方剂学杂志》2024年第13期67-75,共9页高飞 于博睿 谢惠迪 周盈 史扬 张先慧 柳红芳 
国家自然科学基金项目(81774273);北京市自然科学基金项目(7212180);2022年东直门医院科技创新项目(DZMKJCX-2022-003);2023年东直门医院科技创新项目(DZMKJCX-2023-005);北京中医药大学“揭榜挂帅”项目(2023-JYBJBZD-023)。
目的:探讨芪地糖肾方(QDTS)调控糖尿病肾病(DN)足细胞焦亡的分子机制。方法:体内实验将db/db小鼠分为模型组、芪地糖肾方(3.34 g·kg^(-1))和缬沙坦胶囊(10.29 mg·kg^(-1))组,db/m小鼠作为正常组,每组8只,连续干预8周。末次给药后处死...
关键词:芪地糖肾方 糖尿病肾病 足细胞损伤 焦亡 分子机制 
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