RelA/p65磷酸化:驱动癌症进展的关键修饰  

Phosphorylation of RelA/p65:a crucial modification driving cancer progression

作　　者：曹硕 孙许涛[1] 吴思雨 毛彩云 宋运佳 CAO Shuo;SUN Xutao;WU Siyu;MAO Caiyun;SONG Yunjia(School of Basic Medicine,Heilongjiang University of Chinese Medicine,Harbin 150000,China)

机构地区：[1]黑龙江中医药大学基础医学院,哈尔滨150000

出　　处：《生命的化学》2025年第3期381-393,共13页Chemistry of Life

基　　金：国家自然科学基金项目(82205056);黑龙江省自然科学基金优秀青年基金项目(YQ2022H020)。

摘　　要：p65磷酸化是NF-κB信号通路的重要调控机制,广泛参与了细胞增殖、凋亡、炎症和免疫应答等多种生理病理的调控。p65磷酸化能够诱导多种与癌症相关的基因表达,同时通过影响细胞存活与凋亡来影响癌症的进展。在癌症中,NF-κB通路通常异常激活,尤其是p65磷酸化还影响了肿瘤环境中的炎症,进一步推动癌症进展。因此,p65磷酸化被认为是多个癌症类型中的潜在治疗靶点,通过影响其活性有望阻止肿瘤的生长和扩散。Phosphorylation of p65 serves as a critical regulatory mechanism in the NF-κB signaling pathway,playing a significant role in the regulation of various physiological and pathological processes including cell proliferation,apoptosis,inflammation,and immune responses.Phosphorylation of p65 can induce the expression of genes associated with cancer and impact cell survival and apoptosis,thus influencing cancer progression.Aberrant activation of the NF-κB pathway,particularly phosphorylation of p65,is commonly observed in cancer,affecting inflammation within the tumor microenvironment and further driving cancer progression.Therefore,phosphorylation of p65 is considered a potential therapeutic target in various types of cancer,with the potential to inhibit tumor growth and metastasis by modulating its activity.

关 键 词：RelA/p65 磷酸化 癌症 NF-ΚB 

分 类 号：R730.2[医药卫生—肿瘤]