Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report  

作　　者：Xiao-Yu Zhao Juan-Han Yu Yi-Hua Wang Yi-Xin Liu Lu Xu Lin Fu Ning Yi 

机构地区：[1]China Medical University,The First Hospital of China Medical University,Shenyang 110001,Liaoning Province,China [2]Department of Pathology,The First Hospital of China Medical University,Shenyang 110001,Liaoning Province,China [3]Anshan Cancer Hospital,Anshan 114000,Liaoning Province,China

出　　处：《World Journal of Clinical Cases》2025年第1期48-55,共8页世界临床病例杂志（英文）

摘　　要：BACKGROUND Ependymoma with lipomatous differentiation is a rare type of ependymoma.The ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system tumors.ZFTA fusion-positive lipomatous ependymoma has not been reported to date.CASE SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six minutes.Magnetic resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital cortex.Microscopic examination showed characteristic perivascular pseudorosettes and adipose differentiation in the cytoplasm.Immunohisto-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 protein.Signi-ficant punctate intracytoplasmic EMA immunoreactivity was observed.The level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was performed.The follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance imaging.CONCLUSION Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous differentiation.This case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关 键 词：EPENDYMOMA Lipomatous Molecular classification SUPRATENTORIAL ZFTA:RELA fusion Case report 

分 类 号：R73[医药卫生—肿瘤]