N-亚硝基芬氟拉明的液相色谱-质谱/质谱联用检测及化学合成  

Liquid Chromatography-Mass Spectrometry/Mass Spectrometry Combined Use Detection and Chemical Synthesis of N-Nitrosfenfluramine

作　　者：徐淑周 王琳 王琛 侯玉乾 张诗敏 谢洪磊 Xu Shuzhou;Wang Lin;Wang Chen;Hou Yuqian;Zhang Shimin;Xie Honglei(Yantai Key Laboratory of Nanomedicine&Advanced Preparations,Yantai Institute of Materia Medica,Yantai,Shangclong 264000,China)

机构地区：[1]烟台市纳米药物与高端制剂重点实验室烟台药物研究所,山东烟台264000

出　　处：《化学世界》2020年第6期408-410,共3页Chemical World

基　　金：烟台市科技计划(No.2019MSGY128);山东省重点研发计划(No.2019GSF108050)资助项目。

摘　　要：建立了芬氟拉明衍生物的液相色谱-质谱/质谱联用(LC-MS/MS)检测方法,对其中一个衍生物进行化学合成,并经过LC-MS/MS和1H NMR表征。This article aims to establish a specific method for the identification of fenfluramine derivatives.Under the condition of selected chromatogram,one derivative of fenfluramine was detected and chemically synthesized. The product was identified by using liquid chromatography-mass spectrometry/mass spectrometry combined use(LC-MS/MS)and 1 H NMR.

关 键 词：芬氟拉明衍生物 合成 液相色谱-质谱/质谱联用 

分 类 号：R914.5[医药卫生—药物化学]