晚期结直肠癌患者化疗前后血清CEA、CA-242水平的变化及临床意义  

Serum CEA and CA-242 levels in patients with advanced colorectal cancer before and after chemotherapy

作　　者：黄喜文[1] 郭维 丘惠珍 李恩[3] 黎佳全[1] Huang Xiwen;Guo Wei;Qiu Huizhen;Li En;Li Jiaquan(Second Division,Department of Chemotherapy,Department of Gastrointestinal Surgery,Meizhou,Guangdong 514031,China;Central Laboratory,Department of Gastrointestinal Surgery,Meizhou,Guangdong 514031,China;Fist Division,Department of Gastrointestinal Surgery,Meizhou,Guangdong 514031,China)

机构地区：[1]梅州市人民医院化疗二科,广东梅州514031 [2]梅州市人民医院中心实验室,广东梅州514031 [3]梅州市人民医院胃肠外一科,广东梅州514031

出　　处：《中华生物医学工程杂志》2019年第6期773-776,共4页Chinese Journal of Biomedical Engineering

基　　金：梅州市医药卫生科研课题(2015-B-39)。

摘　　要：目的探索晚期结直肠癌患者化疗前、后血清CEA(癌胚抗原)与CA-242(糖类抗原242)水平变化情况与临床治疗效果的判断价值。方法于2017年1月至2018年12月期间在本院当中选取晚期结直肠癌患者80例,作为结直肠癌组,另选取同期接收80例门诊健康体检人员为健康组,晚期结直肠癌组患者给予化疗,化疗前后分别采用酶联免疫吸附实验对两组人员的血清CEA、CA-242水平进行检测,结合随访复查的影像检查结果,客观评价上述肿瘤标志物检测与晚期结直肠癌组的化疗效果的关联。结果晚期结直肠癌组血清CEA、CA-242水平显著高于健康组(P<0.05),80例患者中,CR 2例,PR 40例,SD 20例,PD 18例,总有效率为52.5%,疾病控制率为77.5%,治疗有效的患者化疗后的血清CEA、CA-242水平均显著低于化疗前(P<0.05);化疗前后CR、PR、SD患者血清CEA、CA-242水平均显著低于PD患者(P<0.05);而化疗后CR、PR患者的血清CEA、CA-242水平又均显著低于SD患者(P<0.05)。结论检测血清CEA水平和CA-242水平对于判断晚期结直肠癌患者治疗效果有很好的临床应用价值。Objective To investigate the changes in serum carcinoembryonic antigen(CEA)and carbonhydrate antigen(CA)-242 levels before and after chemotherapy,and their clinical value for evaluation of treatment outcomes in patients with advanced colorectal cancer.Methods Included in this study were 80 patients with advanced colorectal cancer(colorectal cancer group)in our hospital between January 2017 and December 2018.A contemporary cohort of 80 healthy checkup individuals were selected as the control group.Patients with advanced colorectal cancer were given chemotherapy.Enzyme-linked immunosorbent assay was used before and after chemotherapy to detect the serum CEA and CA-242 levels in the two groups.Based on the follow-up imaging review,the correlation between these tumor biomarkers and the efficacy of chemotherapy in advanced colorectal cancer group was objectively evaluated.Results The serum CEA and CA-242 levels in the advanced colorectal cancer group were significantly higher than those in the control group(P<0.05).Among the 80 patients,there were 2 with complete remission(CR),40 with partial remission(PR),20 with stable disease(SD),and 18 with progression of disease(PD),yielding an overall response rate of 52.5%and a disease control rate of 77.5%.Serum CEA and CA-242 levels in patients who responded to treatment were significantly lower than those at baseline(P<0.05).The serum CEA and CA-242 levels in patients with CR,PR,and SD were significantly lower than those in PD patients either at baseline or after chemotherapy(P<0.05).The serum CEA and CA-242 levels in patients with CR and PR were significantly lower than those in SD patients after chemotherapy(P<0.05).Conclusion Detection of serum CEA and CA-242 levels is of great clinical value for determining the treatment outcomes in patients with advanced colorectal cancer.

关 键 词：晚期结直肠癌 临床疗效 血清CEA、CA-242 

分 类 号：R735[医药卫生—肿瘤]