环状RNAs与急性缺血性卒中  

Circular RNAs and acute ischemic stroke

作　　者：左蕾 姚红红[2] 闫福岭[1] Zuo Lei;Yao Honghong;Yan Fuling(Department of Neurology,Zhongda Hospital,Southeast University,Nanjing 210009,China)

机构地区：[1]东南大学附属中大医院神经内科,南京210009 [2]东南大学医学院药理系,南京210009

出　　处：《国际脑血管病杂志》2020年第5期386-390,共5页International Journal of Cerebrovascular Diseases

摘　　要：近年来,与卒中相关的环状RNAs(circular RNAs, circRNAs)被广泛研究,其变化涉及卒中的多个病理生理学环节,包括血管生成、神经可塑性、细胞凋亡和神经炎症等。进一步探明特定circRNAs在急性缺血性卒中后的变化及其涉及的分子生物学机制,有助于开发可能的新型药物靶点进而改善患者预后。文章对急性缺血性卒中后发生变化的主要circRNAs以及circRNAs的作用机制、功能检测方法及目前研究所面临的挑战进行了综述。Objective In recent years,circular RNAs(circRNAs)related to stroke has been widely studied,and its change involves multiple pathophysiological aspects of stroke,including angiogenesis,neural plasticity,cell apoptosis,and neuroinflammation.Further exploration of the changes of specific circRNAs after acute ischemic stroke and the molecular biological mechanisms involved will help to develop possible new drug targets and improve the prognosis of patients.This article reviews the main circRNAs that have changed after acute ischemic stroke,and their mechanism of action,functional detection methods,and challenges faced by the current research.

关 键 词：卒中 脑缺血 RNA 环状 

分 类 号：R743.3[医药卫生—神经病学与精神病学]