雷帕霉素洗脱支架与金属裸支架置入犬基底动脉后的对比研究  

A comparative study of rapamycin eluting stents and bare metal stents in the canine basilar artery

作　　者：杨永凯 张帆[2] 周晓辉 吴彩松 何心光 魏书山 吴桥 Yang Yongkai;Zhang Fan;Zhou Xiaohui;Wu Caisong;He Xinguang;Wei Shushan;Wu Qiao(Department of Neurosurgery,the First Hospital of Fuzhou City Affiliated Fujian Medical University,Fuzhou 350009,China;Department of Neurosurgery,Fuzhou Second Hospital Affiliated to Xiamen University,Fuzhou 350007,China)

机构地区：[1]福建医科大学附属福州市第一医院神经外科,350009 [2]厦门大学附属福州市第二医院神经外科,350007

出　　处：《中华实验外科杂志》2020年第4期689-692,共4页Chinese Journal of Experimental Surgery

基　　金：福建省重大专项专题项目(2015YZ0003-1);福州市卫生计生科技创新平台建设项目(2018-S-wp2)。

摘　　要：目的通过雷帕霉素洗脱支架与金属裸支架置入拉布拉多犬基底动脉的动物实验,探讨置入犬基底动脉的颅内雷帕霉素洗脱支架的安全性和有效性。方法由上海甲干生物科技有限公司提供的健康成年拉布拉多犬18条随机分为对照组(A组)、钴铬支架组(B组)、雷帕霉素洗脱支架组(C组),不同类型的支架置入到相应组别犬基底动脉,分别在术后30、60、90 d行血管造影测量支架置入处基底动脉管腔直径,采用犬神经功能评分方法评估犬神经功能,测量评估后处死犬行大脑组织学检查。组间比较用配对t检验。结果在术后30 d A、B及C组犬基底动脉管腔直径差异无统计学意义[(1.51±0.01) mm比(1.52±0.04) mm,t=1.038,P>0.05;(1.51±0.01) mm比(1.50±0.03) mm,t=0.913,P>0.05;(1.52±0.04) mm比(1.50±0.03) mm,t=1.316,P>0.05],在术后60 d及90 d C组血管直径较A组和B组粗大,差异均有统计学意义[(1.23±0.04) mm比(1.43±0.02) mm,t=9.867,P<0.05;(1.21±0.01) mm比(1.43±0.02) mm,t=10.548,P<0.05;(1.10±0.03) mm比(1.31±0.02) mm,t=9.317,P<0.05;(1.07±0.04) mm比(1.31±0.02) mm,t=12.512,P<0.05],A组和B组之间差异无统计学意义[(1.23±0.04) mm比(1.21±0.01) mm,t=0.627,P>0.05;(1.10±0.03) mm比(1.07±0.04) mm,t=0.864,P>0.05]。在术后30 d及60 d A、B及C组神经功能评分差异无统计学意义[(3.15±0.27)分比(2.89±0.64)分,t=1.341,P>0.05;(3.15±0.27)分比(3.23±0.47)分,t=0.976,P>0.05;(2.89±0.64)分比(3.23±0.47)分,t=1.183,P>0.05;(4.12±0.19)分比(4.21±0.25)分,t=0.943,P>0.05;(4.12±0.19)分比(3.44±0.54)分,t=1.852,P>0.05;(4.21±0.25)分比(3.44±0.54)分,t=1.980,P>0.05],在术后90 d C组犬神经功能评分明显低于A组和B组,差异均有统计学意义[(6.00±0.63)分比(3.50±0.42)分,t=12.843,P<0.05;(6.50±0.54)分比(3.50±0.42)分,t=13.148,P<0.05],A组和B组比较差异无统计学意义[(6.00±0.63)分比(6.50±0.54)分,t=0.871,P>0.05]。在术后30、60、90 d造影复查后处死犬行大脑组织学检查未发现�Objective To compare the safety and efficiency in rapamycin eluting intracranial stents by experimental study on the implantation of rapamycin eluting stent and bare metal stent into the labrador canine Basilar artery.Methods A total of 18 labrador dogs,were randomly divided into control group(A group),Cobalt chromium alloy stent group(B group)and rapamycin eluting stent group(C group).Different types of stents were implanted into the corresponding groups of canine basilar artery.The diameters of the basilar artery were measured at the similar point of every dog on the 30th,60th and 90th day after the stent implantation.The neurological function scores were compared in the three groups after the stent implantation.After measuring the diameter,the dogs were sacrificed for brain histological examination.Results There was no significant difference in the diameter of the basilar artery among the three group on the 30th day after the stent implantation[(1.51±0.01)mm vs.(1.52±0.04),t=1.038,P>0.05;(1.51±0.01)mm vs.(1.50±0.03)mm,t=0.913,P>0.05;(1.52±0.04)mm vs.(1.50±0.03)mm,t=1.316,P>0.05].The diameter of the basilar artery in group C was significantly larger than that in group A and B on the 60th day and 90th day after the stent implantation,the difference was statistically significant[(1.23±0.04)mm vs.(1.43±0.02)mm,t=9.867,P<0.05;(1.21±0.01)mm vs.(1.43±0.02)mm,t=10.548,P<0.05;(1.10±0.03)mm vs.(1.31±0.02)mm,t=9.317,P<0.05;(1.07±0.04)mm vs.(1.31±0.02)mm,t=12.512,P<0.05].There was no significant difference in the diameter of the basilar artery between group A and group B[(1.23±0.04)mm vs.(1.21±0.01)mm,t=0.627,P>0.05;(1.10±0.03)mm vs.(1.07±0.04)mm,t=0.864,P>0.05].There was no significant difference in the neurological function scores among the three group on the 30th day and 60th day after the stent implantation(3.15±0.27 vs.2.89±0.64,t=1.341,P>0.05;3.15±0.27 vs.3.23±0.47,t=0.976,P>0.05;2.89±0.64 vs.3.23±0.47,t=1.183,P>0.05);(4.12±0.19 vs.4.21±0.25,t=0.943,P>0.05;4.12±0.19 vs.3.44±0.54,t=1.852,P

关 键 词：药物洗脱支架 雷帕霉素 基底动脉 支架置入 

分 类 号：R743[医药卫生—神经病学与精神病学]