艾司西酞普兰与文拉法辛治疗老年焦虑症效果比较  

Comparison of the effects of escitalopram and venlafaxine in the treatment of senile anxiety

作　　者：王艳蓉 韩海平[1] WANG Yanrong;HAN Haiping(Department of Neurology,People's Hospital of Ningxia Hui Autonomous Region,Yinchuan 750001,China)

机构地区：[1]宁夏回族自治区人民医院神经内科,银川市750001

出　　处：《临床合理用药杂志》2020年第16期25-26,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的比较艾司西酞普兰与文拉法辛治疗老年焦虑症的临床效果。方法选取2018年3月-2019年2月宁夏回族自治区人民医院神经内科诊治的老年焦虑症患者106例,按照用药方案不同分为观察组和对照组,每组53例。观察组采取艾司西酞普兰治疗,对照组采取文拉法辛治疗。比较2组临床疗效、汉密尔顿焦虑量表(HAMA)评分及不良反应发生情况。结果观察组总有效率为96. 23%,略高于对照组的90. 57%,但差异无统计学意义(χ~2=1. 377,P=0. 241)。用药后2组HAMA评分均逐渐下降(P <0. 01);观察组用药1周时HAMA评分低于对照组(P <0. 01),而用药2周、4周及6周时2组HAMA评分比较差异均无统计学意义(P> 0. 05)。观察组不良反应发生率为15. 09%低于对照组的32. 08%(χ~2=4. 240,P=0. 039)。结论艾司西酞普兰治疗老年焦虑症的效果与文拉法辛相当,但艾司西酞普兰具有起效快、不良反应发生率低等优点。Objective To compare the effects of escitalopram and venlafaxine in the treatment of senile anxiety.Methods 106 cases of elderly anxiety patients admitted to department of Neurology,the People’ s Hospital of Ningxia Hui Autonomous Region from March 2018 to February 2019 were selected,according to different medication regimens,they were divided into observation group( 53 cases) and control group( 53 cases). The observation group was treated with escitalopram,and the control group was treated with venlafaxine. The clinical efficacy,the scores of HAMA,and adverse drug reactions were compared between the 2 groups. Results The total effective rate in observation group( 96. 23%) was slightly higher than that of control group( 90. 57%),but the difference was not statistically significant( χ^2= 1. 377,P = 0. 241). After treatment,the HAMA scores of both groups gradually decreased( P < 0. 01);The HAMA score of observation group was lower than that of control group at 1 week of medication( P < 0. 01),while at 2 weeks,4 weeks and 6 weeks,there was no statistically significant difference in HAMA score between the two groups( P > 0. 05). The incidence of adverse reactions in observation group( 15. 09%) was lower than that of control group( 32. 08%)( χ^2= 4. 240,P = 0. 039). Conclusion The effect of escitalopram on senile anxiety is similar to venlafaxine,but escitalopram has the advantages of fast onset and low incidence of adverse reactions.

关 键 词：艾司西酞普兰 文拉法辛 焦虑症 不良反应 

分 类 号：R749.72[医药卫生—神经病学与精神病学]