喹硫平对酒依赖预防复饮作用的meta分析  

The effect of quetiapine for preventing the relapse in patients with alcohol dependence:a meta-analysis

作　　者：杨清艳[1] 张怡 陈科[1] 张勇[1] 赵荣江[1] 牛雅娟[1] 杨可冰[1] YANG Qingyan;ZHANG Yi;CHEN Ke;ZHANG Yong;ZHAO Rongjiang;NIU Yajuan;YANG Kebing(Beijing Huilongguan Hospital,Beijing,100096,China;Tianjin Binhai New Area Tanggu Anding Hospital,Tianjin,300454,China)

机构地区：[1]北京回龙观医院,北京100096 [2]天津市滨海新区塘沽安定医院,天津300454

出　　处：《中国药物依赖性杂志》2020年第2期136-141,共6页Chinese Journal of Drug Dependence

基　　金：北京市属医院科研培育项目(2017067);北京市卫生与健康科技成果和适宜技术推广项目(2018-TG-22);北京中医药科技发展资金项目(JJ2018-07);北京市医院管理局临床医学发展专项(XMLX201834)。

摘　　要：目的:使用meta分析的方法探索喹硫平对酒依赖患者预防复饮的作用。方法:在Pubmed、Embase、The Cochrane Library、Web of Science、Ovid和中国知网、万方数据库、维普中文科技期刊数据库进行中英文文献的检索,对检索到的文献进行系统文献筛查,将符合入组标准的文献进行meta分析。结果:最终纳入3篇文献,总样本量341人,meta分析结果显示,服用喹硫平的酒依赖患者与安慰剂组的复饮率差异无统计学意义(OR=0.707,95%CI=0.707~2.209,P=0.551>0.05)。结论:临床使用喹硫平作为预防酒依赖患者复饮的治疗措施仍需谨慎,需要更大样本量、更高质量的研究进一步提供支持证据。Objective:We used meta-analysis to explore the effect of quetiapine for preventing the relapse in patients with alcohol dependence.Methods:We searched Pubmed,Embase,The Cochrane Library,Web of Science,Ovid,China Knowledge Network,Wanfang database,Weipu China Science and Technology Journal Database to search English and Chinese papers,and then we systematically screened the papers.We conducted meta-analysis of the papers meeting the inclusion criteria.Results:Three articles were included in the study with the total sample size of 341.The meta-analysis showed no significant difference in the relapse rate between the patients with alcohol dependence and the placebo group(OR=0.707,95%CI=0.707~2.209,P=0.551>0.05).Conclusion:It should be cautious to use quetiapine as a treatment for preventing relapse in patients with alcohol dependence in clinic,and further researches are needed to provide larger sample size and higher quality studies.

关 键 词：酒依赖 喹硫平 复饮 META分析 

分 类 号：R749[医药卫生—神经病学与精神病学]