血清脂蛋白(a)水平与胆囊结石并发胆囊炎的相关性研究  

Relationship between Serum Lipoprotein(a)Level and Gallstone Complicated by Cholecystitis

作　　者：施瑞洁[1] 闫福堂[1] 杨娜[1] 苍金荣[1] 刘文康[1] 迟洁[1] 袁军[1] SHI Rui-jie;YAN Fu-tang;YANG Na;CANG Jing-rong;LIU Wen-kang;CHI Jie;YUAN Jun(Department of Clinical Laboratory,Shaanxi Provincial People’s Hospital,Xi’an 710068,China)

机构地区：[1]陕西省人民医院检验科,西安710068

出　　处：《现代检验医学杂志》2020年第3期78-80,共3页Journal of Modern Laboratory Medicine

基　　金：国家高技术研究发展计划(863计划)项目(2014AA022304)。

摘　　要：目的探讨血清脂蛋白(a)[lipoprotein(a),LP(a)]在胆囊结石伴胆囊炎疾病中的临床意义。方法收集2017年3月~2018年9月临床确诊为胆囊结石伴胆囊炎患者126例和92例胆囊炎患者的血清标本,以陕西省人民医院健康体检中心的147例健康体检者的血清标本作为对照组,采用免疫透射比浊法并使用日立7170全自动生化分析仪检测受检者血清Lp(a)水平。结果胆囊结石伴胆囊炎患者组、单纯胆囊炎患者组和健康对照组血清中Lp(a)分别为369.2±258.5,168.6±110.3和165.9±135.8 mg/L,胆囊结石伴胆囊炎患者组Lp(a)水平均明显高于单纯胆囊炎患者组和健康对照组(t=6.391,6.100,均P<0.01),而单纯胆囊炎患者组与健康对照组之间血清Lp(a)水平差异无统计学意义(t=0.261,P>0.05)。各实验组中男性受检者和女性受检者的血清Lp(a)水平的差异均无统计学意义(t=0.1006,P>0.05);单纯胆囊炎男性患者和女性患者血清Lp(a)水平与健康对照受检者的差异均无统计学意义(t=0.1321,P>0.05),但是胆囊结石伴胆囊炎男性和女性患者血清Lp(a)水平均明显高于单纯胆囊炎患者组和健康对照组(t=6.100~6.391,P<0.01)。结论相比单纯胆囊炎患者,胆囊结石伴胆囊炎患者血清Lp(a)水平会升高,Lp(a)对临床诊断胆囊结石伴胆囊炎有指导作用。Objective To explore the clinical significance of lipoprotein(a)[Lp(a)]in gallstone complicated by cholecystitis.Methods The serum specimens were collected from 126 cases of patients diagnosed as gallstone complicated by cholecystitis,92 ones diagnosed as cholecystitis and 147 ones as control group from physical examination center of Shaanxi Province People’s Hospital from March 2017 to August 2018.The serum Lp(a)concentration was detected on the principle of transmitted turbidimetry by Hitachi 7170 Automatic Biochemical Analyzer.Results The means of serum Lp(a)concentration in gallstone complicated by cholecystitis group,cholecystitis one and healthy control one were 369.2±258.5,168.6±110.3 and 165.9±135.8mg/L,respectively.The mean of serum Lp(a)concentration in gallstone complicated by cholecystitis group was higher than that in cholecystitis one and healthy control one,respectively(t=6.100,6.391,P<0.01),but there was no statistical difference for serum Lp(a)concentration between cholecystitis group and healthy control one(t=0.261,P>0.05).The serum Lp(a)concentration in male examinees had no statistical difference from that in female ones in all groups,respectively(t=0.1006,P>0.05).The serum Lp(a)concentration of males in cholecystitis group had no statistical difference from that of females,so did in healthy control group(t=0.1321,P>0.05),but the mean of serum Lp(a)concentration of males in gallstone complicated by cholecystitis group was respectively higher than that of males in cholecystitis one and healthy control one,so was that of females(t=6.100~6.391,P<0.01).Conclusion The serum Lp(a)level increased in patients with gallstone complicated by cholecystitis compared with that in those with cholecystitis and it may be helpful to diagnose gallstone complicated by cholecystitis by mean of serum Lp(a)concentration.

关 键 词：脂蛋白(a) 单纯胆囊炎 胆囊结石伴胆囊炎 

分 类 号：R575.6[医药卫生—消化系统] R446.112[医药卫生—内科学]