免疫细胞在慢加急性肝衰竭中的调控作用  

Regulatory effects of immune cells on acute-on-chronic liver failure

作　　者：李彦霖 杨雪亮[2] 刘小静[3] 吴剑华 王一川 Li Yanlin;Yang Xueliang;Liu Xiaojing;Wu Jianhua;Wang Yichuan(First College of Clinical Medicine,Xi’an Jiaotong University Health Science Center,Xi’an 710061,China;Department of Nutrition,First Hospital Affiliated to Xi’an Jiaotong University,Xi’an 710061,China;Department of Infectious Diseases,First Hospital Affiliated to Xi’an Jiaotong University,Xi’an 710061,China;Second College of Clinical Medicine,Xi’an Jiaotong University Health Science Center,Xi’an 710061,China)

机构地区：[1]西安交通大学医学部第一临床医学院,西安710061 [2]西安交通大学第一附属医院营养科,西安710061 [3]西安交通大学第一附属医院感染科,西安710061 [4]西安交通大学医学部第二临床医学院,西安710061

出　　处：《中国肝脏病杂志（电子版）》2020年第2期42-46,共5页Chinese Journal of Liver Diseases：Electronic Version

基　　金：陕西省自然科学基础研究计划(2017JM8083)。

摘　　要：慢加急性肝衰竭(acute-on-chronic liver failure,ACLF)是一种以慢性肝病病理损伤为基础,以不同程度肝细胞坏死性病变为特征的病理过程,其具体发生机制尚未完全明确,但各种免疫细胞在其中发挥重要作用已有共识。本文通过阐述临床和动物研究中多种免疫细胞在ACLF发生发展中的变化,了解ACLF免疫学发病机制,以期为临床治疗ACLF提供科学依据。Acute-on-chronic liver failure(ACLF)is a pathological process characterized by liver cell necrotizing lesions of varying degrees based on the pathological injury of chronic liver disease.Although the specific mechanism is not completely clear,there is a consensus that various immune cells play important roles.In this paper,the changes of various immune cells in the development of ACLF in clinical and animal studies were expounded to understand the pathogenesis of ACLF immunology,so as to provide scientific basis for clinical treatment of ACLF.

关 键 词：肝功能衰竭 慢加急性 免疫细胞 调控作用 

分 类 号：R575.3[医药卫生—消化系统]