月经和生育因素与肺癌风险关系的Meta分析  

Menstrual and reproductive factors and lung cancer risk a Meta analysis

作　　者：段寒英 杨菲燕 王智琪 李勇[2,5] 朱冠嘉[1,2] 成天然 张森炎 韩大婷 张文轩 王朝阳 DUAN Hanying;YANG Feiyan;WANG Zhiqi;LI Yong;ZHU Guanjia;CHENG Tianran;ZHANG Senyan;HAN Dating;ZHANG Wenxuan;Wang Chaoyang(Clinical Medical College of Henan University,Kaifeng 475000,China;Evidence Based Medicine Center of Henan University,Kaifeng 475000,China;Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430022,China;China Japan Friendship Hospital,Beijing 100020,China;Department of Cardiothoracic Surgery Huaihe Hospital of Henan University,Kaifeng 475000,China;Institute of EvidencēBased Medicine and Knowledge Translation Henan University,Kaifeng 475000,China;Department of General Surgery Huaihe Hospital of Henan University,Kaifeng 475000,China)

机构地区：[1]河南大学临床医学院,河南开封475000 [2]河南大学循证医学中心,河南开封475000 [3]华中科技大学同济医学院附属协和医院,武汉430022 [4]北京大学中日友好医院,北京100020 [5]河南大学淮河医院心胸外科一病区,河南开封475000 [6]河南大学循证医学与临床转化研究院,河南开封475000 [7]河南大学淮河医院普外科,河南开封475000

出　　处：《河南大学学报（医学版）》2020年第2期126-134,共9页Journal of Henan University:Medical Science

摘　　要：[目的]肺癌在女性中的发病率越来越高,其机制可能与女性雌激素表达水平较高有关,通过Meta分析探讨女性月经和生育因素与肺癌风险的关系。[方法]在Pubmed、Embase、中国知网、万方及维普数据库中搜索2020年1月15日前的相关文献。共纳入10篇符合标准的文献。应用Review Manager 5.3软件进行Meta分析。[结果]分析结果表明绝经年龄与肺癌风险没有统计学关联(RR=0.98;95%CI=0.88~1.09)。较大月经初潮年龄(>13岁)的北美女性(RR=0.95;95%CI=0.91~0.99)和较大首次活产年龄(≥30岁)的北美女性(RR=0.86;95%CI=0.76~0.98)患肺癌的风险降低。较低胎次(0~2)是北美女性患肺癌的危险因素(RR=1.07;95%CI=1.01~1.13)和亚洲女性患肺癌的保护因素(RR=0.63;95%CI=0.53~0.75)。[结论]绝经年龄与肺癌风险无相关性。较大月经初潮年龄和较大首次活产年龄的北美女性的肺癌发病率降低。较低的胎次是北美女性患肺癌的危险因素和亚洲女性患肺癌的保护因素。[Objective]The incidence of lung cancer in women is getting higher and higher,and its mechanism may be related to the higher expression level of female estrogen.We explore the relationship between menstruation and fertility factors and female lung cancer risk through meta-analysis.[Methods]The Pubmed,Embase,CKNI,WANFANG DATA and VIP were searched by computer and the searcher deadline was Jan 15,2020.Ten articles of the standards-compliant literature were included.Review Manager 5.3 was applied for meta-analysis.[Results]The results showed there was no statistically significant association between menopausal age and lung cancer risk(RR=0.98;95%CI:0.88-1.09).Older age at menarche in North American women(>13 years old)(RR=0.95;95%CI=0.91~0.99)and older age at first live birth in North American women(≥30 y)(RR=0.86;95%CI=0.76~0.98)were associated with a significant decreased risk of lung cancer.Low parity(0-2)was a risk factor for North America female lung cancer(RR=1.07;95%CI=1.01~1.13)and a protective factor for Asia female lung cancer(RR=0.63;95%CI=0.53~0.75).[Conclusion]Age at menopause were not significantly associated with lung cancer risk.Older age at menarche in North American women and older age at first live birth in North American women were associated with a significant decreased risk of lung cancer.Low parity was a risk factor for North America female lung cancer and a protective factor for Asian female lung cancer.

关 键 词：肺癌 绝经年龄 初潮年龄 首次活产年龄 胎次 雌激素 

分 类 号：R734.2[医药卫生—肿瘤]