糖尿病视网膜病变发病机制及潜在治疗研究进展  

Pathogenesis and potential treatment of diabetic retinopathy

作　　者：张凤俊[1] 李晶明[1] 刘秋平[1] ZHANG Fengjun;LI Jingming;LIU Qiuping(Department of Ophthalmology,Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi Province,China)

机构地区：[1]南昌大学附属眼科医院眼科,江西省南昌市330006

出　　处：《眼科新进展》2020年第7期677-685,共9页Recent Advances in Ophthalmology

基　　金：国家自然科学基金(编号81960177,81740158);江西省自然科学基金(编号20192BAB205049)。

摘　　要：随着人们生活方式以及饮食结构的改变,糖尿病逐渐成为全球公共卫生问题。世界卫生组织报道最新的全球糖尿病患者多达4.22亿人,预计到2040年将达6.42亿人,而中国糖尿病患者数将位居世界第一。糖尿病视网膜病变(diabetic retinopathy,DR)是糖尿病最常见的眼部并发症,常发生在1型糖尿病患者患病5 a内以及所有的2型糖尿病患者患病20 a后,已成为全球主要致盲原因。如何阻止或减缓DR进展,将成为全球防控可致盲眼病的关键。本文对DR早期的发病机制及目前潜在的治疗策略进行简要综述,以期有助于相关领域的进一步研究和寻找更多有效的DR防治方法。With the change of people’s lifestyle and diet structure,diabetes has gradually become a global public health issue.The World Health Organization reports that prevalence of diabetes is 422 million worldwide,which is expected to reach 642 million by 2040.China ranks first in the world with the largest population affected by diabetes.Diabetic retinopathy(DR)is one of the most common ocular complications of diabetes mellitus,which often occurs within 5 years after the onset of type 1 diabetes and 20 years after the onset of type 2 diabetes.Thus,DR has become the leading cause of blindness.How to prevent or slow down the progress of DR is essential for prevention of vision threatening eye diseases.In this paper,the current pathogenesis and potential treatment strategies for DR are briefly reviewed in order to inspire the further research direction and seek for the novel therapeutic targets.

关 键 词：糖尿病视网膜病变 炎症 氧化应激 硝基化应激 表观遗传修饰 线粒体损伤 基因多态性 视网膜神经变性 血管内皮祖细胞功能障碍 自噬 昼夜节律 

分 类 号：R774.1[医药卫生—眼科]