ME-NBI联合卢戈氏液染色在食管癌高危人群筛查中的诊断价值  

Diagnostic value of ME-NBI combined with Lugol's solution staining in screening high-risk population of esophageal cancer

作　　者：刘云云 王玉欣 朱季军 王艳 王晓燕 LIU Yunyun;WANG Yuxin;ZHU Jijun;WANG Yan;WANG Xiaoyan(Department of Gastroenterology, Suqian First People's Hospital, Suqian 223800, Jiangsu, China)

机构地区：[1]宿迁市第一人民医院消化内科,江苏宿迁223800

出　　处：《西部医学》2020年第7期1007-1011,共5页Medical Journal of West China

基　　金：宿迁市科技支撑计划项目(S201629)。

摘　　要：目的探讨窄带成像放大内镜(ME-NBI)联合卢戈氏液染色内镜在食管癌高危人群筛查中的诊断价值。方法选择2016年1月~2018年12月在我院消化内镜中心进行食管癌高危人群筛查的500例患者作为研究对象,所有患者均接受白光内镜检查、ME-NBI及ME-NBI结合卢戈氏液色素内镜镜下诊断,以活检病理或手术术后病理结果为金标准,共筛出198例病变患者,病变处共260例,食管早癌共73例,统计分析三种方法诊断食管早癌灵敏度、特异度、准确度。结果 ME-NBI结合卢戈氏液染色内镜诊断食管早癌准确度明显高于白光内镜、ME-NBI检查(χ~2=34.531,P<0.001;χ~2=11.134,P=0.001);ME-NBI结合卢戈氏液染色内镜诊断食管早癌灵敏度、特异度高于白光内镜(χ~2=39.806,P<0.001χ~2=14.457,P<0.001);ME-NBI结合卢戈氏液染色诊断食管早癌灵敏度、特异度高于ME-NBI诊断(χ~2=17.843,P<0.01;χ~2=0.205,P=0.651)。结论 ME-NBI联合卢戈氏液染色可以提高食管癌高危人群食管黏膜病变检出的准确度,并且对食管早癌检测的灵敏度和特异度较高,可在临床推广应用。Objective To investigate the diagnostic value of ME-NBI combined with Lugol's solution staining in screening high-risk population of esophageal cancer.Methods From January 2016 to December 2018,500 patients who were screened in the digestive endoscopy center of our hospital for high-risk esophageal cancer were selected as the research objects.All patients were diagnosed by white light endoscopy,me NBI and me NBI combined with Lugol's liquid pigment endoscopy.198 patients were screened out with pathological changes,260 cases in total,and the pathological results after biopsy or hand operation were taken as the gold standard The sensitivity,specificity and accuracy of three methods were analyzed.Results The accuracy of ME-NBI combined with Lugol's liquid staining endoscopy in the diagnosis of early esophageal cancer was significantly higher than that of white light endoscopy and ME-NBI(2=34.531,P<0.001,2=11.134,P=0.001).The sensitivity and specificity of ME-NBI combined with Lugol's liquid staining endoscopy in the diagnosis of early esophageal cancer were significantly higher than that of white light endoscopy(2=39.806,P<0.001,2=14.457,P<0.001).ME-NBI combined with Lugol's solution staining was more sensitive and specific than ME-NBI in the diagnosis of early esophageal cancer,but there was no significant difference in specificity(2=17.843,P<0.01,2=0.205,P=0.651).Conclusion ME-NBI combined with Lugol's solution staining endoscopy screening for high-risk groups of esophageal cancer can improve the diagnostic accuracy,specificity and sensitivity of early esophageal cancer.

关 键 词：食管癌 高危人群 窄带成像放大内镜 卢戈氏液内镜 

分 类 号：R735.1[医药卫生—肿瘤]