恩替卡韦联合复方甘草酸苷治疗乙型肝炎肝硬化对患者肝功能及血清HA、Ⅳ-C、PC-Ⅲ水平的影响  

Effects of entecavir combined with compound glycyrrhizin on liver function and serum levels of HA,Ⅳ-C and PC-Ⅲin patients with hepatitis B cirrhosis

作　　者：何慧霞[1] 刘丽 王蕾[1] He Huixia;Liu Li;Wang Lei(Department of Digestive System,the Third People’s Hospital of Zhengzhou,Zhengzhou 450000,China)

机构地区：[1]河南省郑州市第三人民医院消化内科,450000

出　　处：《中国实用医刊》2020年第1期90-93,共4页Chinese Journal of Practical Medicine

摘　　要：目的 探讨恩替卡韦联合复方甘草酸苷治疗乙型肝炎肝硬化对患者肝功能及血清透明质酸(HA)、Ⅳ型胶原(Ⅳ-C)、Ⅲ型前胶原(PC-Ⅲ)水平的影响.方法 选取2017年1月至2018年12月郑州市第三人民医院收治的86例乙型肝炎肝硬化患者为研究对象,采用随机数字表法分为观察组和对照组,每组43例.对照组给予恩替卡韦治疗,观察组在此基础上加用复方甘草酸苷进行治疗.比较两组疗效,分析两组患者肝功能、血清纤维化指标及免疫功能指标的变化情况,记录两组不良反应发生情况.结果 观察组治疗有效率为95.35%(41/43),高于对照组的79.07%(34/43),P<0.05.治疗后,两组白蛋白(ALB)水平均升高,天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、总胆红素(TBiL)水平均降低,且观察组治疗后ALB水平高于对照组,AST、ALT、TBiL水平低于对照组(P<0.05).治疗后,两组层粘连蛋白(LN)、HA、PC-Ⅲ、Ⅳ-C水平均降低,且观察组治疗后LN、HA、PC-Ⅲ、IV-C水平均低于对照组(P均<0.05).治疗后,两组CD4+、CD4+/CD8+均升高,CD8+均降低,且观察组治疗后CD4+、CD4+/CD8+均高于对照组,CD8+低于对照组(P<0.05).两组均未出现明显不良反应.结论 恩替卡韦联合复方甘草酸苷治疗乙型肝炎肝硬化患者疗效确切,可显著改善患者肝功能及免疫功能状态,缓解肝纤维化,安全有效.Objective To investigate the effects of entecavir combined with compound glycyrrhizin on liver function and serum levels of hyaluronic acid(HA),typeⅣcollagen(Ⅳ-C)and typeⅢprocollagen(PC-Ⅲ)in patients with hepatitis B cirrhosis.Methods Eighty-six patients with hepatitis B cirrhosis admitted to the Third People’s Hospital from January 2017 to December 2018 were selected for the study.And they were divided into observation group and control group by random number table method,with 43 cases in each group.Patients in the control group were given entecavir,and patients in the observation group were given combined therapy of compound glycyrrhizin and entecavir.The therapeutic effects of the two groups were compared.The effects of therapy on liver function,serum fibrosis and immune function indexes were analyzed,and the occurrence of adverse reactions was recorded.Results The effective rate of treatment in the observation group was 95.35%(41/43),significantly higher than the 79.07%(34/43)in the control group(P<0.05).After treatment,the levels of albumin(ALB)in the two groups were significantly increased,while the levels of aspartate aminotransferase(AST),alanine aminotransferase(ALT)and total bilirubin(TBiL)were significantly decreased in the two groups(P<0.05).After treatment,the level of ALB in observation group was significantly higher than that in control group,while the levels of AST,ALT and TBiL were significantly lower than those in control group(P<0.05).After treatment,the levels of laminin(LN),HA,PC-ⅢandⅣ-C were significantly decreased,and the levels of LN,HA,PC-ⅢandⅣ-C in observation group were significantly lower than those in control group(P<0.05).After treatment,the cluster of differentiation(CD)4+and CD4+/CD8+were significantly increased,while the CD8+was significantly decreased in both groups(P<0.05).Moreover,the CD4+and CD4+/CD8+in the observation group were significantly higher than those in the control group after treatment,while the CD8+was significantly lower than that in control gro

关 键 词：恩替卡韦 复方甘草酸苷 乙型肝炎肝硬化 肝功能 透明质酸 Ⅳ-型胶原 Ⅲ型前胶原 

分 类 号：R575[医药卫生—消化系统] R51[医药卫生—内科学]