美沙拉嗪联合双岐杆菌四联活菌胶囊治疗溃疡性结肠炎的效果观察  

Effects of mesalazine combined with Bifidobacterium tetravaccine capsules on ulcerative colitis

作　　者：王巧玲[1] Wang Qiaoling(Department of Gastroenterology,the Fifth People’s Hospital of Datong,Datong 037009,China)

机构地区：[1]山西省大同市第五人民医院消化内科,037009

出　　处：《中国实用医刊》2020年第5期100-102,共3页Chinese Journal of Practical Medicine

摘　　要：目的观察美沙拉嗪联合双岐杆菌四联活菌胶囊治疗溃疡性结肠炎(UC)的效果。方法选取2017年5月至2018年4月大同市第五人民医院治疗的124例UC患者作为研究对象,根据随机数字表法将其分为观察组和对照组,每组62例。对照组给予美沙拉嗪,观察组在对照组治疗基础上加用双岐杆菌四联活菌胶囊。观察两组患者的临床疗效、治疗前后炎症免疫反应及不良反应发生情况。结果治疗后,观察组总有效率(93.55%,58/62)高于对照组(79.03%,49/62),P<0.05。治疗前,两组免疫球蛋白A(IgA)、免疫球蛋白G(IgG)及肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL-10)水平比较差异未见统计学意义(P>0.05);治疗后,观察组IgA、IgG、TNF-α水平[(1.32±0.58)g/L、(8.16±0.54)g/L、(271.59±32.34)ng/L]低于对照组[(1.75±0.34)g/L、(10.59±0.47)g/L、(346.65±40.08)ng/L],IL-10水平[(159.52±35.24)ng/L]高于对照组[(98.74±33.61)ng/L],差异有统计学意义(P<0.05)。两组不良反应发生率比较差异未见统计学意义(P>0.05)。结论UC患者接受美沙拉嗪、双岐杆菌四联活菌胶囊联合治疗更有助于抑制炎症反应,改善免疫功能,且安全有效。Objective To observe the effects of mesalazine combined with Bifidobacterium tetravaccine capsules on ulcerative colitis(UC).Methods A total of 124 patients with UC treated in the Fifth People’s Hospital of Datong from May 2017 to April 2018 were selected as research objects,and they were divided into two groups by the random number table method,with 62 cases in each group.The control group was treated with mesalazine,and the observation group was treated with Bifidobacterium tetravaccine capsules and mesalazine.Clinical efficacy,inflammatory immune response and adverse reactions of the two groups were observed before and after treatment.Results After treatment,the total efficiency of the observation group was 93.55%(58/62),higher the 79.03%(49/62)of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of immunoglobulin A(IgA),immunoglobulin G(IgG),tumor necrosis factor-α(TNF-α)or interleukin-10(IL-10)between the two groups(P>0.05).After treatment,the levels of IgA,IgG and TNF-a in the observation group were(1.32±0.58)g/L,(8.16±0.54)g/L,(271.59±32.34)ng/L,respectively,lower than the(1.75±0.34)g/L,(10.59±0.47)g/L,(346.65±40.08)ng/L in the control group(P<0.05);on the contrary,IL-10 level in the observation group was higher than the control group after treatment,with statistically significant differences(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Methalazine combined with Bifidobacterium tetravaccine capsules in the treatment of UC patients is more helpful to suppress inflammatory response,improve immune function,and it is safe and effective.

关 键 词：溃疡性结肠炎 美沙拉嗪 双岐杆菌四联活菌胶囊 炎症免疫反应 

分 类 号：R574.62[医药卫生—消化系统]