丁苯酞联合颈动脉支架置入术治疗眼缺血综合征的效果  

Effects of Butylphthalide combined with carotid artery stenting in the treatment of ocular ischemia syndrome

作　　者：王辉[1] 张强[1] 申向辉[1] 王海波[1] 孟艳枝 侯晓英[1] WANG Hui;ZHANG Qiang;SHEN Xianghui;WANG Haibo;MENG Yanzhi;HOU Xiaoying(Functional Branch,Handan Central Hospital,Hebei Province,Handan 056001,China)

机构地区：[1]河北省邯郸市中心医院功能科,河北邯郸056001

出　　处：《中国医药导报》2020年第18期127-130,共4页China Medical Herald

基　　金：河北省医学科学研究重点课题计划项目(20171136)。

摘　　要：目的观察丁苯酞联合颈动脉支架置入术治疗眼缺血综合征(OIS)的治疗效果。方法选取2017年11月~2018年1月河北省邯郸市中心医院收治的106例OIS患者纳入本研究,按照随机数字表法将其分为常规组(53例)与丁苯酞组(53例)。两组患者均行颈动脉支架置入术治疗,常规组给予围术期常规治疗,丁苯酞组在常规组治疗的基础上应用丁苯酞治疗。术后20 d,观察两组患者视力水平,视网膜中央动脉(CRA)血流动力学指标[收缩期峰值流速(SPV)、舒张期峰值流速(EDV)、阻力指数(RI)],颈部病变动脉血流动力学指标(SPV、EDV)及美国国立卫生院神经缺血评分(NIHSS)的变化情况。结果治疗前,两组患者患眼视力水平比较,差异无统计学意义(P>0.05);治疗后,两组患者患眼视力水平均较治疗前改善,且丁苯酞组优于常规组,差异均有统计学意义(均P <0.05)。治疗后,两组患者患眼CRA的SPV、EDV均较治疗前升高,RI有所降低,且丁苯酞组SPV、EDV均高于常规组,RI低于常规组,差异均有统计学意义(均P <0.05)。治疗后,两组患者SPV、EDV、NIHSS均较治疗前降低,且丁苯酞组低于常规组,差异均有统计学意义(均P <0.05)。结论丁苯酞应用于颈动脉支架置入术中能够有效提高患者术后视力水平,改善患者视网膜中央动脉与颈部动脉的血流动力学指标。Objective To observe the therapeutic effect of Butylphthalide combined with carotid artery stenting in the treatment of ocular ischemia syndrome(OIS). Methods A total of 106 OIS patients who admitted to Handan Central Hospital, Hebei Province from November 2017 to January 2018 were included in the study. They were divided into the conventional group(53 cases) and the Butylphthalide group(53 cases) according to random number table method. Patients in both groups were treated with carotid artery stenting, the conventional group received perioperative conventional treatment, and the Butylphthalide group was treated with Butylphthalide on the basis of the conventional group treatment. Postoperative 20 d, the changes of visual acuity level, hemodynamic indexs of central retinal artery(CRA)(systolic peak velocity [SPV], end diastolic peak velocity [EDV], resistance index [RI]), cervical lesions arterial blood flow mechanics index(SPV, EDV) and the US national institutes of health stroke scale(NIHSS) in the two groups were observed. Results Before treatment, there was no statistically significant difference in the visual acuity between the two groups(P > 0.05). After treatment, the visual acuity level of both groups was improved compared with that before treatment, and the Butylphthalide group was superior to the conventional group, with statistically significant differences(all P < 0.05). After treatment, SPV and EDV of ocular CRA in both groups were increased compared with those before treatment, while RI was decreased. SPV and EDV in the Butylphthalide group were higher than those in the conventional group, while RI was lower than that in the conventional group, and the differences were statistically significant(all P < 0.05). After treatment, SPV, EDV and NIHSS of patients in the two groups were all lower than those before treatment, and Butylphthalide group was lower than the conventional group, with statistically significant differences(all P < 0.05). Conclusion The application of Butylphthalide in carotid artery

关 键 词：眼缺血综合征 颈动脉狭窄 颈动脉支架植入术 丁苯酞 视网膜中央动脉 

分 类 号：R743.3[医药卫生—神经病学与精神病学]