前列腺癌患者血清miR-152、miR-32表达及其意义  

Expression and Significance of Serum miR-152 and miR-32 in Patients with Prostate Cancer

作　　者：丁宁 张志辉[1] 程伟[1] 何建光[1] 汪珂[1] DING Ning;ZHANG Zhi-hui;CHENG Wei(Xian Gaoxin Hospital,Xi'an 710075)

机构地区：[1]西安高新医院泌尿外科,陕西西安710075

出　　处：《医学临床研究》2020年第6期840-842,共3页Journal of Clinical Research

摘　　要：【目的】探讨前列腺癌患者血清miR-152、miR-32水平的变化及与病理学分期及Gleason评分的关系.【方法】选取2016年1月至2018年5月本院收治的前列腺癌患者(观察组,n=80)及前列腺增生患者(对照组,n=80).检测并对比两组血清miR-152、miR-32水平,并按照病理学分期、PSA及Gleason评分进行分层分析.【结果】观察组患者血清m iR-32水平显著高于对照组,差异有统计学意义(P<0.05);观察组患者血清m iR-152水平显著低于对照组,差异有统计学意义(P<0.05).不同病理学分期、是否发生淋巴结转移的前列腺癌患者血清miR-152水平比较,差异有统计学意义(P<0.05);不同Gleason评分的前列腺癌组患者血清m iR-152水平比较,差异无统计学意义(P>0.05).不同病理学分期、是否发生淋巴结转移、不同Gleason评分的前列腺癌患者的血清miR-32水平组间比较,差异有统计学意义(P<0.05).【结论】前列腺癌患者血清m iR-152水平显著地降低、m iR-32水平显著升高,并且与患者的临床病理特征密切相关.【Objective】To investigate the changes of serum miR-152 and mir-32 levels in patients with prostate cancer and their relationship with pathological stage and Gleason score.【Methods】From January 2016 to may 2018,patients with prostate cancer(observation group,n=80)and patients with prostate hyperplasia(control group,n=80)were selected.The serum levels of miR-152 and miR-32 were detected and compared between the two groups,and stratified analysis was performed according to the pathological stage,PSA and Gleason score.Hierarchical analysis was performed according to pathological staging,PSA and Gleason scores.【Results】The level of serum miR-32 in the observation group was significantly higher than that in the control group(P<0.05);the level of serum miR-152 in the observation group was significantly lower than that in the control group(P<0.05).There was significant difference in serum miR-152 level between patients with prostate cancer of different pathological stages and lymph node metastasis(P<0.05);there was no significant difference in serum miR-152 level of prostate cancer patients with different Gleason scores(P>0.05).There were statistically significant differences in serum mir-32 levels among prostate cancer patients with different pathological stages,lymph node metastasis and Gleason score(P<0.05).【Conclusion】The serum miR-152 level of prostate cancer patients decreased significantly,the miR-32 level increased significantly,and both are closely related to the clinicopathological characteristics of the patients.

关 键 词：前列腺肿瘤/病理学 微RNAS 

分 类 号：R737.25[医药卫生—肿瘤]