临床药师参与1例肺腺癌患者TP化疗方案给药顺序的病例分析  

Clinical pharmacists participate in the administration sequenc of TP chemotherapy of a patient with lung adenocarcinoma

作　　者：陈超 叶晓芬 金美玲 蔡映云 吕迁洲 CHEN Chao;YE Xiaofen;JIN Meiling;CAI Yingyun;LYU Qianzhou(Department of Pharmacy,the People’s Hospital of Xiangxi Autonomous Prefecture,Hu’nan Jishou 416000,China;Department of Pharmacy,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Department of Respiratory Medicine,Zhongshan Hospital,Fudan University,Shanghai 200032,China)

机构地区：[1]湘西土家族苗族自治州人民医院药剂科,湖南吉首416000 [2]复旦大学附属中山医院药剂科,上海200032 [3]复旦大学附属中山医院呼吸科,上海200032

出　　处：《上海医药》2020年第13期57-59,共3页Shanghai Medical & Pharmaceutical Journal

摘　　要：1例49岁男性肺腺癌患者住院期间使用TP化疗方案(紫杉醇+顺铂),静脉滴注顺序为紫杉醇(30 mg,1 h)→顺铂(60 mg,3.2 h)→紫杉醇(210 mg,3.3 h)。临床药师依据药物的代谢途径、相互作用及不良反应等特点,提出对于TP化疗的方案应该紫杉醇先用,顺铂后用的给药建议。同时总结肿瘤化疗方案的给药顺序原则,为临床合理用药提供参考。A 49-year-old man with lung adenocarcinoma was treated with TP chemotherapy regimens(paclitaxel+cisplatin)during the hospitalization.The sequence of intravenous drip is paclitaxel(30 mg,1 h)→cisplatin(60 mg,3.2 h)→paclitaxel(210 mg,3.3 h).The clinical pharmacist proposed the administration of paclitaxel before cisplatin(paclitaxel→cisplatin)based on the characteristics of the drug’s metabolic pathways,their interactions and adverse reactions.This recommendation was accepted by clinicians and adverse reactions did not occur.The principle of the administration sequence of tumor chemotherapy regimen was summarized so as to provide a reference for rational clinical medication.

关 键 词：化疗方案 给药顺序 临床药师 

分 类 号：R734.2[医药卫生—肿瘤] R730.53[医药卫生—临床医学]