基于心音信号的一种血压评估方法  

Blood pressure estimation based on heart sound signals

作　　者：成谢锋[1] 戴世诚 赵鹏军 Cheng Xie-Feng;Dai Shi-Cheng;Zhao Peng-Jun(College of Electronic and Optical Engineering,Nanjing University of Posts and Telecommunications,Nanjing 210023,China;Pediatric Cardiology,Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China)

机构地区：[1]南京邮电大学电子与光学工程学院,南京210023 [2]上海交通大学附属新华医院,小儿心脏病学,上海200092

出　　处：《物理学报》2020年第14期271-280,共10页Acta Physica Sinica

基　　金：国家自然科学基金(批准号:61271334)资助的课题.

摘　　要：心血管疾病尤其是高血压已成为人类生命健康最大杀手之一.本文探究主动脉瓣心音信号与血压之间的关系,提出一种基于心音信号的无创血压估计方法.首先,根据血压与心音信号的关系,提取第一心音和第二心音峰值点的时间间隔以及第二心音的峭度作为特征;接着将第一心音和第二心音峰值点的时间间隔、第二心音的峭度与所测收缩压和舒张压进行线性拟合;最后根据第一心音和第二心音峰值点的时间间隔、第二心音的峭度与血压的线性关系,提出基于心音的血压评估公式.实验结果表明,第一心音和第二心音峰值点的时间间隔、第二心音的峭度能够作为血压评估的特征参数,与血压具有良好的线性关系,其拟合优度分别为0.801和0.765,通过本文推导出的血压计算公式所得血压与商用电子血压计测量值的平均误差小于5 mmHg,标准偏差小于8 mmHg.本文提出基于心音对血压进行评估的一种新方法,可用于血压的连续测量,针对某些特殊条件下,具有显著的应用前景.Cardiovascular disease,especially hypertension,has become one of the biggest killers of human life and health.Therefore,early detection and prevention of cardiovascular diseases are of great significance for people’s health.In this paper,we explore the relationship between aortic valve heart sound signal and blood pressure,and propose a method of non-invasively estimating blood pressure based on heart sound signals.First,according to the relationship between blood pressure and the heart sound signal,both the time interval between the peak point of the first heart sound and that of the second heart sound and the kurtosis of the second heart sound are extracted as features.Then the time interval between the first heart sound and the second heart sound,and the kurtosis of the second heart sound are linearly fitted to the measured blood pressure.Finally,according to the linear relationship between heart sound and blood pressure,a blood pressure evaluation formula based on the heart sound is established.The experimental results show that the time interval between the peak point of the first heart sound and that of the second heart sound,and the kurtosis of the second heart sound can be used as the characteristic parameters of blood pressure evaluation,which have a good linear relationship with blood pressure.The goodness of fit is 0.801 and 0.765,separately.The average error between the blood pressure calculated from the blood pressure calculation formula and the blood pressure measured by a commercial electronic sphygmomanometer is less than 5 mmHg,and the standard deviation is less than 8 mmHg.For hypertensive patients,the time interval between the peak point of the first heart sound and the second heart sound is shortened,and the kurtosis of the second heart sound is increased,which is a typical feature of heart sounds in patients with hypertension.Compared with the traditional blood pressure calculation method,the blood pressure assessment method proposed in this paper only needs to collect heart sound signals t

关 键 词：血压 主动脉瓣心音 峰值检测 峭度 

分 类 号：R540.4[医药卫生—心血管疾病]