首发精神分裂症患者泌乳素水平与认知功能的关系  

Relationship between serum prolactin and cognitive function in patients with first episode schizophrenia

作　　者：吕伟 朱程[1] 郑克[1] 刘家洪[1] 刘林晶[1] LYU Wei;ZHU Cheng;ZHENG Ke;LIU Jiahong;LIU Linjing(Department of General Psychiatry,the Affiliated Kangning Hospital of Wenzhou Medical University,Wenzhou 325000,China)

机构地区：[1]温州医科大学附属康宁医院普通精神科,浙江温州325000

出　　处：《温州医科大学学报》2020年第8期666-669,共4页Journal of Wenzhou Medical University

摘　　要：目的:分析首发精神分裂症患者外周血中泌乳素(PRL)含量和认知功能与正常人的差异,并进一步分析二者之间的联系。方法:选取2018年1月至12月温州医科大学附属康宁医院精神分裂症患者和正常体检者各80例,分别作为病例组和对照组,运用重复性成套神经心理状态测验(RBANS)评定精神分裂症患者和正常对照者的认知功能水平,同时检测外周血中PRL含量。对数据进行Pearson相关分析和线性逐步回归分析。结果:病例组外周血中PRL含量显著高于对照组,病例组RBANS总分以及各因子分显著低于对照组,差异有统计学意义(P<0.05)。精神分裂症患者PRL含量与RBANS总分及视觉广度和言语功能因子分呈负相关(r=-0.423、-0.271、-0.352,P<0.05),PRL含量与即刻记忆、注意及延时记忆无相关性(P>0.05)。PRL含量均进入以RBANS总分、视觉广度和言语功能因子分为因变量的回归方程,PRL含量可以分别解释RBANS总分变异的25.70%、视觉广度因子分变异的14.70%、言语功能因子分变异的19.60%(P<0.05)。结论:精神分裂症患者存在PRL含量的升高和认知功的损害,精神分裂症患者PRL水平的异常与其认知功能损害有一定的关联。Objective:To compare the levels of serum prolactin and cognitive function between first episode schizophrenic patients and healthy controls,and further analyze the relationship between cognitive function and homocysteine in schizophrenic patients.Methods:Eighty first episode schizophrenic patients and eighty normal persons were selected as case group and control group from January to December 2018 in the Affiliated Kangning Hospital of Wenzhou Medical University.After entering the group,the plasma level of prolactin and the score of Repeatable Battery for the Assessment of Neuropsychological Status(RBANS)were measured in schizophrenic patients and healthy controls.The collected data were analyzed by correlation analysis and stepwise regression analysis.Results:The serum level of prolactin in schizophrenic patients was significantly higher than that in healthy controls,while the total score of RBANS and its factor scores in schizophrenic patients were significantly lower than that in healthy controls(P<0.05).The serum prolactin level was negatively correlated with the total score of RBANS,the factor score of visual span and speech function(r=-0.423,-0.271,-0.352,P<0.05),but not with the factor score of attention,immediate memory and delayed memory(P>0.05).The serum prolactin level entered the regression equation with RBANS total score,visual span and speech function factors score as dependent variables,that could explain 25.70%,14.70%and 19.60%of the changes of RBANS total score,visual span and speech function factors score respectively(P<0.05).Conclusion:Patients with schizophrenia have elevated serum prolactin levels and cognitive impairment.The abnormity of serum prolactin in patients with schizophrenia is associated with cognitive impairment.

关 键 词：首发精神分裂症 泌乳素 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]