microRNA调控肝星状细胞活化干预肝癌癌前病变的研究进展  

Advances in the role of microRNA in the intervention of malignant transformation of precancerous lesions of the liver by regulating the activation of hepatic stellate cells

作　　者：吴杰 李京涛 魏海梁 闫曙光[1] 范妤[1] 郭英君[3] 常占杰 WU Jie;LI Jingtao;WEI Hailiang;YAN Shuguang;FAN Yu;GUO Yingjun;CHANG Zhanjie(The First Clinical Medical College of Shaanxi University of Chinese Medicine,Xianyang,Shaanxi 712046,China;Department of Hepatology,The Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang,Shaanxi 712046,China;The People’s Hospital of Ningxia Hui Autonomous Region,Yinchuan 750001,China)

机构地区：[1]陕西中医药大学第一临床医学院,陕西咸阳712046 [2]陕西中医药大学附属医院肝病科,陕西咸阳712046 [3]宁夏回族自治区人民医院肝病科,银川750001

出　　处：《临床肝胆病杂志》2020年第7期1650-1654,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金项目(81603612);陕西省科技厅科研基金项目(2016SF-234、2018KJXX-093);陕西省教育厅基金(16JK1212);陕西省中管局基金(15-JC008);陕西省“特支计划”区域发展人才项目(2017);宁夏回族自治区自然科学基金(NZ17278);陕西中医药大学学科创新团队建设项目(2019-YL05)。

摘　　要：在肝癌的进展中,其发生发展呈多阶段性:肝炎-肝硬化-肝癌癌前病变-肝癌。其中肝癌癌前病变恶性转变与肝星状细胞(HSC)活化密切相关,通过叙述活化的HSC与肝癌癌前病变细胞的产生、炎症纤维化微环境的形成,以及两者的相互作用。提出microRNAs可通过调控相关靶基因的表达,发挥调节HSC活化,进而影响肝癌癌前病变恶性转变的作用,这方面研究有望成为肝癌防治的新思路、新靶点。The development and progression of liver cancer have the stages of hepatitis,liver cirrhosis,precancerous lesion,and liver cancer,among which the malignant transformation of precancerous lesions of liver cancer is closely associated with the activation of hepatic stellate cells(HSC).By describing the activation of HSC,the generation of precancerous cells of liver cancer,the formation of inflammatory fibrotic microenvironment,and the association between HSC activation and precancerous lesion,this article points out that microRNAs can affect the malignant transformation of precancerous lesion of liver cancer by regulating the expression of related target genes and HSC activation,and the research in this field is expected to provide new ideas and targets for the prevention and treatment of liver cancer.

关 键 词：肝肿瘤 癌前状态 肝星状细胞 微RNAS 

分 类 号：R735.7[医药卫生—肿瘤]