microRNA-27a在多种肝脏疾病发生发展中的作用机制  

Mechanism of action of microRNA-27a in the development and progression of liver diseases

作　　者：罗昕 徐铭益[1] LUO Xin;XU Mingyi(Department of Gastroenterology,Shanghai First People’s Hospital,Shanghai Jiao Tong University,Shanghai 200080,China)

机构地区：[1]上海交通大学附属第一人民医院消化内科,上海200080

出　　处：《临床肝胆病杂志》2020年第7期1666-1668,共3页Journal of Clinical Hepatology

基　　金：国家自然科学基金(81570547,81770597);国家科技部“十三五”重大专项(2017ZX10203202003005)。

摘　　要：microRNA(miRNA)是小分子非编码RNA,可通过转录后基因表达的调控来调节多种生理和病理功能。越来越多的证据表明miRNA-27a在肝病的发展和发病机制中发挥了作用。通过总结相关研究,介绍了miRNA-27a在脂肪肝、肝炎、肝纤维化及肝癌等多种肝脏疾病中作用的研究进展,也分析了miRNA-27a在肝脏再生中的作用以及作为生物标志物的潜能。通过对miRNA-27a在慢性肝病发生发展中相关机制的总结归纳,可以对后续的相关研究提供相应的借鉴,对探索慢性肝病新的治疗思路提供更多的可能性。microRNAs(miRNAs)are low-molecular-weight non-coding RNAs that regulate various physiological and pathological functions through the regulation of gene expression at the post-transcriptional level.More and more evidence has shown that microRNA-27a(miRNA-27a)plays a role in the development and pathogenesis of liver diseases.By reviewing and updating related studies,this article introduces the research advances in the role of miRNA-27a in various liver diseases including fatty liver disease,hepatitis,hepatic fibrosis,and liver cancer and analyzes the role of miRNA-27a in liver regeneration and its potential as a biomarker,so as to provide a reference for future studies and more possibilities for new treatment ideas for chronic hepatic diseases.

关 键 词：微RNAS 脂肪肝 肝炎 肝硬化 肝肿瘤 肝再生 

分 类 号：R575[医药卫生—消化系统] R512.6[医药卫生—内科学]