肝硬化后肝癌患者的临床特征及肝硬化进展为肝癌的危险因素  

Clinical features of liver cancer patients after cirrhosis and influencing factors of developing liver cancer in cirrhosis

作　　者：黄培宁[1] 程吉云[1] 余贤恩[1] 韦凯扬[1] 彭乃宝[1] 蓝常明[1] HUANG Pei-ning;CHENG Ji-yun;YU Xian-en;WEI Kai-yang;PENG Nai-bao;LAN Chang-ming(Department of Gastroenterology,People′s Hospital of Baise,Baise 533000,China)

机构地区：[1]广西百色市人民医院消化内科,百色市533000

出　　处：《广西医学》2020年第12期1494-1497,共4页Guangxi Medical Journal

基　　金：广西医药卫生科研课题(Z2013116)。

摘　　要：目的分析肝硬化后肝癌的临床特征及肝硬化进展为肝癌的危险因素。方法回顾性分析200例肝硬化患者的临床资料,其中发生癌变100例(观察组),未发生癌变100例(对照组)。采用多因素Logistic回归模型分析肝硬化进展为肝癌的危险因素。结果 100例肝硬化后肝癌患者以年龄≥50岁、男性为主,乙型病毒性肝炎是最常见的病因。年龄≥50岁、男性、酗酒>10年、HBV感染均是肝硬化进展为肝癌的危险因素(均P<0.05)。结论肝硬化后肝癌患者以中老年人、男性为主,病因主要是乙型病毒性肝炎;年龄≥50岁、男性、酗酒>10年、HBV感染的肝硬化进展为肝癌的风险增大。Objective To analyze the clinical features of liver cancer after cirrhosis and the influencing factors of developing liver cancer in cirrhosis. Methods The clinical features of 200 cirrhosis patients were analyzed retrospectively, including 100 cases with cancerization(observation group) and 100 cases without cancerization(control group). Multivariate Logistic regression model was used to analyze the risk factors for developing liver cancer in cirrhosis. Results Among the 100 patients with liver cancer after cirrhosis, a majority of the patients were at the age of 50 or above and male cases, and the most common etiology was hepatitis B. Age of 50 or above, males, duration of excessive drinking longer than 10 years, and HBV infection were the risk factors for developing liver cancer in cirrhosis(all P<0.05). Conclusion Patients with post-cirrhosis liver cancer are commonly middle-aged and elderly people, dominated by males, and the main etiology is hepatitis B;cirrhosis patients with age ≥50 years, being male, with duration of excessive drinking longer than 10 years, or with HBV infection, are at increased risk of developing liver cancer.

关 键 词：肝硬化 肝癌 临床特征 危险因素 乙型病毒性肝炎 酗酒 

分 类 号：R735.7[医药卫生—肿瘤]