缺血性卒中患者血清中热休克蛋白-70、半胱氨酸蛋白酶3水平与TOAST和OCSP分型的关系  

Relationship between serum HSP70 and Caspase-3 levels and TOAST and OCSP typing in patients with ischemic stroke

作　　者：姜慧华 张腾 吴燕飞 JIANG Hui-hua;ZHANG Teng;WU Yan-fei(Department of Neurology,the First People's Hospital of Chun'an County,Chun'an,Zhejiang 311700,China)

机构地区：[1]淳安县第一人民医院神经内科,浙江淳安311700

出　　处：《中国卫生检验杂志》2020年第12期1479-1481,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨缺血性脑卒中患者血清中HSP-70、Caspase-3水平与患者TOAST和OCSP分型及预后的关系。方法将本院2017年11月-2018年11月收治的198例缺血性卒中患者作为研究对象,抽血检测患者血清中HSP70、Caspase-3水平,所有脑卒中患者按照OCSP和TOAST标准进行分型,采用NIHSS评分评价患者神经功能、采用日常生活活动能力表SF-36评价患者生活质量,评价患者预后,分析不同预后患者血清中HSP-70、Caspase-3和TOAST、OCSP分型的关系。结果TOAST分型中CE型HSP-70、Caspase-3水平,明显高于LAA、SUE、SOD、SAO型;OCSP分型中TACI型HSP-70、Caspase-3水平,明显高于POCI、PACI、LACI型;HSP-70低水平组患者入院和出院NIHSS评分均明显低于对应高水平组;上述差异均有统计学意义(P<0.05);HSP-70、Caspase-3、入院时NIHSS评分、TOAST分型-SE、OCSP分型-TACI是患者预后不良的重要危险因素(P<0.05)。结论缺血性脑卒中患者血清中HSP-70、Caspase-3水平是患者预后不良的重要危险因素。Objective To investigate the relationship between serum HSP-70 and Caspase-3 levels and TOAST and OCSP typing and prognosis in patients with ischemic stroke.Methods A total of 198 patients with ischemic stroke in our hospital were selected as the research objects.The serum levels of HSP70 and caspase-3 were detected by blood sampling.All patients were classified according to OCSP and TOAST criteria.The neurological function of patients was evaluated by NIHSS score,and the quality of life was evaluated by SF-36.The prognosis of patients was evaluated by all patients,and the relationship between serum HSP-70,Caspase-3 and TOAST,OCSP typing was analyzed in patients with different prognosis.Results The highest levels of HSP-70 and Caspase-3 in TOAST were significantly higher than those in LAA,SUE,SOD and SAO.The levels of HSP-70 and Caspase-3 in OCSP were significantly higher than those in POCI,PACI and LACI.The NIHSS scores in low-level HSP-70 patients were significantly lower than those in POCI,PACI and LACI groups,with the differences statistically significant(P<0.05).HSP-70,Caspase-3,and NIHSS scores of patients with low level of Caspase-3,NIHSS score,TOAST type-SE and OCSP type-TACI were important risk factors for poor prognosis(P<0.05).Conclusion Serum levels of HSP-70 and Caspase-3 in patients with ischemic stroke are important risk factors for poor prognosis.

关 键 词：缺血性脑卒中 OCSP分型 TOAST分型 热休克蛋白-70 半胱氨酸蛋白酶3 

分 类 号：R743.3[医药卫生—神经病学与精神病学]