手性环状P2N4-型配体/钴簇合物催化芳香酮的不对称氢化反应  

Asymmetric hydrogenation of aromatic ketones catalyzed by chiral cyclic P2N4-type ligand/cobalt cluster

作　　者：王哲 李岩云[1] 高景星[1] WANG Zhe;LI Yanyun;GAO Jingxing(National Engineering Laboratory for Green Chemical Productions of Alcohols-Ethers-Esters,College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,China)

机构地区：[1]厦门大学化学化工学院,醇醚酯化工清洁生产国家工程实验室,福建厦门361005

出　　处：《厦门大学学报（自然科学版）》2020年第4期590-595,共6页Journal of Xiamen University：Natural Science

基　　金：国家自然科学基金(21673190)。

摘　　要：将廉价易得的钴络合物与新型手性胺膦配体原位形成的催化体系用于芳香酮的不对称氢化反应,并考察了温度、氢气压强、KOH用量等对催化反应的影响.结果表明,以氢气为氢源,在KOH存在的条件下,手性环状P2N4-型配体L5与钴簇合物Co4(CO)12原位形成的体系能有效催化多种芳香酮的不对称氢化反应,获得较高的转化率,相应产物手性芳香醇的对映选择性最高可达90%对映体过量(ee).The catalytic system generated in situ from cheap and easily available cobalt complex with novel chiral aminophosphine ligand was applied to the asymmetric hydrogenation of aromatic ketones.The effects of reaction conditions,such as hydrogen pressures,temperature and the amount of KOH on asymmetric hydrogenation are also investigated.It showed that using the hydrogen gas as hydrogen source,the catalytic system formed in situ from chiral cyclic P 2N 4-type ligand L5 and Co 4(CO)12 in the presence of KOH could efficiently catalyze the asymmetric hydrogenation of various aromatic ketones with high conversion,giving the corresponding optical active alcohols with up to 90%enantiomeric excess(ee).

关 键 词：不对称氢化 钴络合物 芳香酮 手性配体 

分 类 号：O643.32[理学—物理化学]