丁苯酞治疗进展性脑梗死建立侧支循环的临床研究  

Effects of Butylphthalide injection on the establishment of collateral circulation and neurological function in patients with progressive cerebral infarction

作　　者：袁旭娟 曾宏亮[1] 罗叶婷[1] YUAN Xujuan;ZENG Hongliang;LUO Yeting(Ganzhou People's Hospital,Jiangxi Province,Ganzhou,Jiangxi 341000,China.)

机构地区：[1]江西省赣州市人民医院,赣州341000

出　　处：《江西医药》2020年第7期807-809,共3页Jiangxi Medical Journal

基　　金：江西省赣州市卫生和计划生育委员会科研计划,编号2017-1-3。

摘　　要：目的观察丁苯酞注射液对进展性脑梗死(PCI)患者侧支循环建立及临床疗效。方法回顾性分析2017年11月-2019年10月我院治疗的82例PCI患者临床资料,依据治疗方法的不同将其分为两组,将接受常规方案治疗的40例患者归入组成对照组,接受常规方案加丁苯酞注射液联合治疗的42例患者作为观察组。比较两组临床疗效、侧支循环建立情况、神经功能、日常活动能力及不良反应。结果观察组总有效率(92.86%)、侧支循环开放率(80.95%)及治疗后Barthel指数评分(67.31±13.46)分高于对照组(75.00%、57.50%)、(52.69±15.70)分,治疗后美国国立卫生研究院卒中量表(NIHSS)评分(7.84±3.29)分低于对照组的(12.87±4.15)分,差异有统计学意义(P<0.05);观察组、对照组不良反应发生率(14.29%、7.50%)相比,差异无统计学意义(P>0.05)。结论在常规治疗基础上,丁苯酞注射液治疗PCI在恢复患者神经功能及侧支循环建立方面效果确切,有利于提升患者日常活动能力,临床应用安全性较高。Objective To observe the effects of butylphthalide injection on the establishment of collateral circulation and neural function in patients with progressive cerebral infarction(PCI). Methods The clinical data of 82 PCI patients treated in our hospital from November 2017 to October 2019 were retrospectively analyzed. They were divided into two groups according to the different treatment methods. The 40 patients who received conventional treatment were included in the control group. Forty-two patients who received conventional regimen combined with butylphthalide injection were used as the observation group. The clinical efficacy, collateral circulation establishment, nerve function, daily activity ability and adverse reactions were compared between the two groups. Results The total effective rate(92.86%), collateral circulation opening rate(80.95%) and Barthel index score(67.31±13.46) after treatment in the observation group were higher than(75.00%, 57.50%) and(52.69±15.70) in the control group. After treatment, the National Institutes of Health Stroke Scale(NIHSS) score(7.84±3.29) was lower than(12.87±4.15) of the control group, and the difference was statistically significant(P<0.05). There was no significant difference in the incidence of reactions between the two groups(P>0.05). Conclusion In addition to conventional therapy, the treatment of PCI with butylphthalide injection is effective in restoring neurological function and collateral circulation in patients.

关 键 词：进展性脑梗死 丁苯酞注射液 侧支循环建立 神经功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]