齐拉西酮序贯方案与利培酮+奥氮平方案治疗精神分裂症急性期兴奋激越症状的对比研究  

A comparative study of sequential therapy of ziprasidone and the therapy of risperidone plus olanzapine in the treatment of excitationand agitation symptoms in acute stage of schizophrenia

作　　者：周海平 陈立勇 张颖 王洪松 ZHOU Haiping;CHEN Liyong;ZHANG Ying;WANG Hongsong(Psychiatric Hospital of Guangzhou Municipal Civil Affairs Bureau,Guangdong,Guangzhou 510430,China)

机构地区：[1]广州市民政局精神病院,广东广州510430

出　　处：《中国医药科学》2020年第12期67-70,共4页China Medicine And Pharmacy

基　　金：广东省梅州市科技计划项目(2014B37)。

摘　　要：目的对比分析齐拉西酮序贯方案与利培酮+奥氮平方案治疗精神分裂症急性期兴奋激越的临床效果。方法选取我院2018年6月~2019年6月精神科收治的84例精神分裂症急性期患者,根据随机数字表法分为两组,A组(n=42)给予齐拉西酮序贯治疗,B组(n=42)给予利培酮+奥氮平治疗,疗程均为8周。观察并记录治疗后两组临床疗效、阳性与阴性症状量表(PANSS)评分、副反应量表(TESS)评分及安全性。结果(1)治疗后A组总有效率高于B组,差异有统计学意义(P<0.05);(2)治疗前两组PANSS、TESS评分比较差异无统计学意义(P>0.05),治疗后两组PANSS、TESS评分均降低(P<0.05),A组低于B组,差异有统计学意义(P<0.05);(3)两组治疗期间均有失眠头痛、坐立不安、体重增加等反应出现,B组不良反应发生率略高于A组,差异无统计学意义(P>0.05)。结论齐拉西酮序贯方案治疗精神分裂症急性期兴奋激越的临床效果显著,能有效改善PANSS、TESS评分,抑制兴奋激越,且安全可靠。Objective To compare and analyze the clinical efficacy of sequential therapy of ziprasidone and the therapy of risperidone plus olanzapine in the treatment of excitation and agitation in acute stage of schizophrenia.Methods 84 patients in acute stage of schizophrenia admitted to and treated in the psychiatric department of our hospital from June 2018 to June 2019 were selected and divided into two groups according to the random number table method.Group A(n=42)was given sequential therapy of ziprasidone,while group B(n=42)was given the therapy of risperidone plus olanzapine,and for both groups,the course of treatment was 8 weeks.The clinical efficacy,positive and negative syndrome scale(PANSS)scores,treatment emergent symptom scale(TESS)scores and safety of the two groups after treatment were observed and recorded.Results(1)After treatment,the total effective rate of group A was higher than that of group B,and the difference was statistically significant(P<0.05).(2)Before treatment,there was no significant difference between the two groups in PANSS scores and TESS scores(P>0.05).After treatment,the PANSS scores and TESS scores of the two groups decreased(P<0.05),and those of group A were lower than those of group B,with statistically significant differences(P<0.05).(3)The adverse reactions(ADRs)such as insomnia,headache,akathisia and weight gain,etc.occurred in both groups during treatment.The incidence of ADRs in group B was slightly higher than that in group A with no statistical significance(P>0.05).Conclusion Sequential therapy of ziprasidone has significant clinical effect on excitation and agitation in acute stage of schizophrenia.It can effectively improve PANSS scores and TESS scores,and inhibit excitation and agitation.In addition,it is safe and reliable.

关 键 词：齐拉西酮序贯 利培酮 奥氮平 精神分裂症急性期 兴奋激越 

分 类 号：R749.3[医药卫生—神经病学与精神病学]