胎盘多肽注射液联合FOLFOX6方案治疗晚期胃癌的近期效果及对患者T细胞免疫功能、生活质量的影响  

Short-term Effect of Placenta Polypeptide Injection Combined with FOLFOX6 Chemotherapy in the Treatment of Advanced Gastric Cancer and Its Effect on T cell Immune Function and Quality of Life

作　　者：蒋志强[1] 王乐 胡剑 JIANG Zhi-qiang;WANG Le;HU Jian(Department of Oncology,Hebei Yiling Hospital,Shijiazhuang 050000,China)

机构地区：[1]河北以岭医院肿瘤科,石家庄050000

出　　处：《临床误诊误治》2020年第7期39-43,共5页Clinical Misdiagnosis & Mistherapy

基　　金：河北省中医药管理局计划项目(2018197)。

摘　　要：目的观察胎盘多肽注射液联合FOLFOX6方案化疗治疗晚期胃癌的近期效果及对患者T细胞免疫功能、生活质量的影响。方法选取2017年8月-2019年3月我院收治的104例晚期胃癌患者,据治疗方法的不同分为观察组58例和对照组46例。观察组予胎盘多肽注射液联合FOLFOX6方案化疗,对照组仅予FOLFOX6方案化疗。比较两组3个化疗周期结束后的近期疗效,治疗前及3个化疗周期结束后两组CD3+、CD4+、CD8+、CD4+/CD8+水平和简明健康状况调查量表(short form 36 health survey questionnaire, SF-36)评分,以及两组治疗期间化疗毒副反应发生情况。结果治疗后观察组治疗总有效率虽略高于对照组,但差异无统计学意义(χ2=1.113,P=0.291)。治疗后,两组SF-36各维度评分均高于治疗前,且观察组SF-36各维度评分升高程度均大于对照组,差异均有统计学意义(P<0.05)。治疗后,对照组CD3+、CD4+、CD4+/CD8+较治疗前降低,CD8+较治疗前升高,观察组CD3+、CD4+、CD4+/CD8+较治疗前升高,CD8+较治疗前降低,差异均有统计学意义(P<0.05);观察组治疗后CD3+、CD4+、CD4+/CD8+高于对照组,CD8+低于对照组,差异均有统计学意义(P<0.05)。治疗期间观察组胃肠道反应、骨髓抑制、白细胞降低发生率均低于对照组(P<0.05或P<0.01)。结论胎盘多肽注射液联合FOLFOX6方案化疗可显著改善晚期胃癌患者T细胞免疫功能,提高其生活质量,并减少化疗毒副反应发生。Objective To observe the short-term effect of placenta polypeptide injection combined with FOLFOX6 chemotherapy in the treatment of advanced gastric cancer and its effect on T cell immune function and quality of life. Methods A total of 104 patients with advanced gastric cancer admitted to our hospital from August 2017 to March 2019 were selected as the study subjects. According to different treatment methods, they were divided into the observation group(n=58) cases and the control group(n=46). The observation group was treated with placenta polypeptide injection combined with FOLFOX6 regimen, while the control group was treated with FOLFOX6 regimen alone. The short-term efficacy of the two groups after three chemotherapy cycles, the levels of CD3+, CD4+, CD8+, CD4+/CD8+ and the score of the Short Form 36 health survey questionnaire(SF-36) before and after three chemotherapy cycles, as well as the occurrence of toxic reactions of chemotherapy during treatment between the two groups were compared. Results Although the total effective rate of treatment in the observation group was slightly higher than that in the control group after treatment(χ~2=1.113, P=0.291). After treatment, the scores of SF-36 in the two groups were higher than those before treatment, and the increase degree of SF-36 in the observation group was higher than that in the control group(P<0.05). After treatment, CD3+, CD4+, and CD4+/CD8+ in the control group were lower than those before treatment, while CD8+ was higher than that before treatment. In addition, CD3+, CD4+, and CD4+/CD8+ in the observation group were higher than those before treatment, whereas CD8+ was lower than that before treatment(P<0.05). CD3+, CD4+, and CD4+/CD8+ in the observation group were higher while CD8+ was lower, as compared with those in the control group(P<0.05). During the treatment period, the incidence of gastrointestinal reaction, myelosuppression and leukopenia in observation group was lower than that in control group(P<0.05 or P<0.01). Conclusion Placental pol

关 键 词：胃肿瘤 胎盘多肽注射液 FOLFOX6化疗 奥沙利铂 

分 类 号：R735.2[医药卫生—肿瘤]