杞菊地黄汤联合诺和锐特充治疗妊娠期糖尿病41例  

Qiju Dihuang Tang Combined with Insulin Aspart in Treating 41 Cases of Gestational Diabetes Mellitus

作　　者：韩慧慧[1] 马娜[1] 张云清[1] 刘运磊[1] 高霞[1] HAN Huihui;MA Na;ZHANG Yunqing;LIU Yunlei;GAO Xia(Yan'an University Affiliated Hospital,Yan'an 716000,China)

机构地区：[1]延安大学附属医院,陕西延安716000

出　　处：《西部中医药》2020年第4期106-108,共3页Western Journal of Traditional Chinese Medicine

基　　金：陕西省教育厅科学研究项目(12JK0717)。

摘　　要：目的:观察杞菊地黄汤联合诺和锐特充治疗妊娠期糖尿病的临床疗效。方法:将82例妊娠期糖尿病患者随机分为两组,每组41例。对照组皮下注射诺和锐特充,观察组在此基础上服用杞菊地黄汤。治疗一个月后,比较两组患者胰岛β细胞功能(HOMA-β)和妊娠结局。结果:总有效率观察组为92.68%(38/41),对照组为78.05%(32/41),2组比较差异有统计学意义(P<0.05)。治疗后,两组餐后2 h血糖及空腹血糖均明显降低,HOMA-β明显升高,组内比较差异均有统计学意义(P<0.05),组间比较差异也有统计学意义(P<0.05);剖宫产率、并发症发生率观察组分别为34.15%(14/41)、14.6%(6/41),对照组分别为60.98%(25/41)、41.46%(17/41),2组比较差异均有统计学意义(P<0.05)。不良新生儿结局发生率观察组为21.95%(9/41),对照组为65.85%(27/41),2组比较,差异有统计学意义(P<0.05)。结论:杞菊地黄汤联合诺和锐特充治疗妊娠期糖尿病患者具有较为满意的疗效,可以有效改善其HOMA-β水平和妊娠结局。Objective:To observe clinical effects of Qiju Dihuang Tang and insulin aspart in the treatment for gestational diabetes mellitus(GDM).Methods:All 82 GDM patients were randomized into two groups,41 cases each group.The control group accepted subcutaneous injection of insulin aspart,and the observation group took Qiju Dihuang Tang orally.To compare isletβ-cell function(HOMA-β)and pregnancy outcome between both groups.Results:Total effective rate of the observation group was 92.68%(38/41),higher than 78.05%(32/41)of the control group,and the difference had statistical meaning between both groups(P<0.05).After treating,2-hour postprandial blood glucose and fasting blood glucose reduced notably in both groups,HOMA-βrose notably,the difference showed statistical meaning within the groups(P<0.05),the difference was statistically significant between both groups(P<0.05),cesarean section rate and the complication incidence of the observation group were 34.15%(14/41)and 14.6%(6/41),lower than 60.98%(25/41)and 41.46%(17/41)of the control group,and the difference presented statistical meaning(P<0.05).The incidence of adverse neonatal outcome in the observation group was 21.95%(9/41),lower than 65.85%(27/41)of the control group,and the difference showed statistical meaning between both groups(P<0.05).Conclusion:Qiju Dihuang Tang and insulin aspart possess satisfactory clinical effects in the treatment for GDM,it could effectively improve HOMA-βlevel and pregnancy outcome.

关 键 词：妊娠期糖尿病 杞菊地黄汤 诺和锐特充 胰岛Β细胞功能 妊娠结局 

分 类 号：R[医药卫生]