一类甾体22-羧酸乙酯的简易合成方法  

Synthesis of A Series of Steroid 22-Carboxylic Acid Ethyl Ester Compounds

作　　者：陈文霞[1] 金家华 吕永辉 王涛[1] 沈大冬 CHEN Wen-xia;JIN Jia-hua;LV Yong-hui;WANG Tao;SHEN Da-dong(Zhejiang Medicine Co.,Ltd.,Xinchang Pharmaceutical Factory,Shaoxing 312500,China;College of Pharmaceutical Science,Zhejiang University of Technology,Hangzhou 310032,China)

机构地区：[1]浙江医药股份有限公司新昌制药厂,浙江绍兴312500 [2]浙江工业大学药学院,浙江杭州310032

出　　处：《精细化工中间体》2020年第2期34-36,40,共4页Fine Chemical Intermediates

摘　　要：改进了一类甾体22-羧酸乙酯化合物的合成,以去氢表雄酮为原料,经过3步反应得到产物,优化条件下总收率69%。该工艺避免了复杂的柱层析纯化过程,具有工业化生产前景。A series of steroid 22-carboxylic acid ethyl ester compounds were obtained with a total yield of 69%through a three-step reaction using dehydroepiandrosterone as the starting material. This process can avoid the complicated purification process of column chromatography and has been industrialized.

关 键 词：甾体22-羧酸乙酯化合物 去氢表雄酮 不对称氢化 

分 类 号：TQ225.24[化学工程—有机化工]