TACE联合 125 I粒子植入治疗原发性肝癌合并肝外转移的疗效分析  

Curative effect analysis of TACE combined with 125 I seed implantation for hepatocellular carcinoma with extrahepatic metastasis

作　　者：朱超[1] 刘会春[1] 胡小四 庞青 周磊[1] 陈石磊 ZHU Chao;LIU Huichun;HU Xiaosi;PANG Qing;ZHOU Lei;CHEN Shilei(Department of Hepatobiliary Surgery,the First Affiliated Hospital of Bengbu Medical College,Bengbu,Anhui 233000,China)

机构地区：[1]蚌埠医学院第一附属医院肝胆外科,安徽蚌埠233000

出　　处：《检验医学与临床》2020年第14期1969-1971,共3页Laboratory Medicine and Clinic

基　　金：安徽省科技攻关基金项目(1501041155);蚌埠医学院研究生科研创新计划项目(Byycxz1924)。

摘　　要：目的探讨经动脉化疗栓塞术(TACE)联合125 I粒子植入治疗原发性肝癌合并肝外转移的安全性、有效性及影响生存时间的因素。方法选取2011年11月至2018年5月在该院行TACE联合125 I粒子植入治疗原发性肝癌合并肝外转移的患者39例,进行回顾性分析,评价其安全性、有效性并分析影响患者生存时间的因素。结果39例患者中,8例完全缓解(CR),20例部分缓解(PR),5例病灶稳定(SD),6例进展(PD),总有效率为71.7%(28/39)。均无严重并发症,无围术期死亡。中位生存时间为19.0个月。3、6、12、24个月累计生存率分别为97.4%、84.6%、61.5%、38.5%。结论TACE联合125 I粒子植入治疗原发性肝癌合并肝外转移安全有效,疗效显著,有一定临床价值。Objective To discuss the safety,effectiveness and factors affecting survival time of transcatheter arterial chemoembolization embolization(TACE)Combined with 125 I seed implantation for hepatocellular carcinoma with extrahepatic metastasis.Methods Retrospectively assessed the 39 patients who had accepted the therapy of TACE combined with 125 I seed implantation for hepatocellular carcinoma with extrahepatic metastasis in the hospital from November 2011 to May 2018 to evaluate the therapy′s safety and effectiveness and analysis the factors affecting the survival time of patients.Results Among the 39 patients,there were 8 complete remission cases,20 partial remission cases,5 stable cases and 6 progressive cases,and the total effective rate is 71.7%(28/39).There were no serious complications or perioperative death.The median survival time is 9 months.The survival rates of the third month,the sixth month,the twelfth and the twenty-fourth month were 97.4%,84.6%,61.5%and 38.5%respectively.Conclusion TACE Combined with 125 I seed implantation for hepatocellular carcinoma with extrahepatic metastasis is safe and effective,especially in clinical effect,and has certain clinical value.

关 键 词：经动脉化疗栓塞术 125 I粒子 肝细胞性肝癌 肝外转移 

分 类 号：R735.7[医药卫生—肿瘤]