Effects of Dachengqi Decoctions Made from Raw Rhubarb and Vinegar-processed Rhubarb on Levels of Endotoxin,NO and TNF-αin Serum  

作　　者：Wen ZHONG Zujie QIN Jiangcun WEI Zhen XIE Xiumei MA Xianyi SHI Fengxian ZHAO Qian HAN 

机构地区：[1]Guangxi International Zhuang Medicine Hospital, Nanning 530201, China [2]Guangxi University of Chinese Medicine, Nanning 530200, China

出　　处：《Medicinal Plant》2020年第3期70-73,共4页药用植物：英文版

基　　金：National Natural Science Foundation of China(No.81360524);Youth Foundation of Guangxi University of Chinese Medicine(No.2019QN036);Project for Improving Basic Scientific Research Ability of Young and Middle-aged Teachers in Colleges and Universities of Guangxi in 2019(No.2019KY0341);Traditional Chinese Medicine Scientific Research Laboratory(Grade III)of National Administration of Traditional Chinese Medicine:Laboratory of Chinese(Zhuang)Medicine Chemical and Quality Analysis(Guo Zhong Yi Yao Fa 2009[21]).

摘　　要：[Objectives]The effects of Dachengqi decoctions made from raw rhubarb and vinegar-processed rhubarb on serum endotoxin,NO and TNF-αlevels were investigated.[Methods]Total 105 mice were randomly divided into Dachengqi decoction made from raw rhubarb groups(6,10 g/kg),Dachengqi decoction made from vinegar-processed rhubarb groups(6,10 g/kg),positive control group,blank control group and model group.After administration at a dose of 20 mL/kg,the levels of endotoxin,NO and TNF-αin serum were determined.The effects of Dachengqi decoctions made from raw rhubarb and vinegar-processed rhubarb on serum endotoxin,NO and TNF-αlevels in mice were compared.[Results]Dachengqi decoctions made from raw rhubarb and vinegar-processed rhubarb both increased the NO level and reduced the endotoxin and TNF-αlevels in serum of ABP mice.[Conclusions]Dachengqi decoctions made from raw rhubarb and vinegar-processed rhubarb have different effects on endotoxin,NO and TNF-αcontents.These changes correspond to the effects of Dachengqi Decoctions made from raw rhubarb and vinegar-processed rhubarb.The change in the content of rhubarb anthraquinones has a certain effect on the efficacy of Dachengqi decoction.

关 键 词：RHUBARB Dachengqi decoction ENDOTOXIN NO TNF-α 

分 类 号：R57[医药卫生—消化系统]