影响脑梗死后轻度认知障碍合并睡眠障碍的相关性因素分析  

Analysis of related factors influencing mild cognitive impairment with sleep disorders after cerebral infarction

作　　者：杨佳慧 黄丽[1] 王小庆 黄梅[1] YANG Jia-hui;HUANG Li;WANG Xiao-qing;HUANG Mei(Special Medical Center,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院特需医疗中心,四川成都610041

出　　处：《实用医院临床杂志》2020年第4期81-84,共4页Practical Journal of Clinical Medicine

摘　　要：目的探讨影响脑梗死后轻度认知障碍(MCI)合并睡眠障碍的相关因素。方法回顾性分析我院402例脑梗死后MCI患者临床资料。记录其睡眠质量状况,并根据睡眠质量分为合并睡眠障碍组(睡眠障碍组)及未合并睡眠障碍组(非睡眠障碍组)。比较两组多导睡眠图参数总睡眠时间(TST)、睡眠潜伏期(SL)、睡眠效率(SE)、快速眼动睡眠时间(REMS)、醒觉指数(AI)及性别、年龄、脑梗死部位、体质量指数(BMI)、病史、疲劳程度疲劳严重程度量表(FSS)、抑郁情绪Beck抑郁问卷(BDI)、焦虑情绪汉密顿焦虑量表(HAMA)等临床特征差异,并分析影响脑梗死后MCI合并睡眠障碍的危险因素。结果402例患者中睡眠障碍组95例,非睡眠障碍组307例。睡眠障碍组TST、SE、REMS低于非睡眠障碍组,SL、AI高于非睡眠障碍组(P<0.05)。两组性别、高血压病史情况比较,差异无统计学意义(P>0.05);睡眠障碍组年龄、BMI、FSS评分、BDI评分、HAMA评分及左半球脑梗死发生率、糖尿病患病率、冠心病患病率均高于非睡眠障碍组(P<0.05)。高龄、左半球脑梗死、高BMI、糖尿病、冠心病、高FSS评分、高BDI评分、高HAMA评分是影响脑梗死后MCI合并睡眠障碍的独立危险因素(P<0.05)。结论高龄、左半球脑梗死、肥胖、糖尿病、冠心病、疲劳感、抑郁及焦虑情绪均能引起脑梗死后MCI患者发生睡眠障碍,临床应及时调整患者生理及心理状态,减轻疾病对睡眠质量的影响。Objective To explore the related factors affecting mild cognitive impairment(MCI)with sleep disorders after cerebral infarction.Methods Clinical data of 402 patients with MCI after cerebral infarction in our hospital were retrospectively analyzed.The sleep quality was recorded.The patients were classified into combined sleep disorder group(sleep disorder group)and non-combined sleep disorder group(non-sleep disorder group)according to the sleep quality.The clinical features of polysomnography parameters such as total sleep time(TST),sleep latency(SL),sleep efficiency(SE),rapid eye movement sleep time(REMS),arousal index(AI)and gender,age,cerebral infarction sites,body mass index(BMI),medical history,fatigue severity scale(FSS)for fatigue degree,Beck depression inventory(BDI)for depression mood and Hamilton anxiety scale(HAMA)for anxiety mood were compared between the two groups,and the risk factors affecting MCI with sleep disorders after cerebral infarction were analyzed.Results Among the 402 patients,there were 95 cases in the sleep disorder group and 307 cases in non-sleep disorder group.The TST,SE and REMS in the sleep disorder group were lower than those in the non-sleep disorder group(P<0.05)while SL and AI were higher than those in the non-sleep disorder group(P<0.05).There were no significant differences in gender and hypertension history between the two groups(P>0.05).Age,BMI,FSS score,BDI score,HAMA score and incidence rate of left hemisphere cerebral infarction,prevalence rate of diabetes and prevalence rate of coronary heart disease in the sleep disorder group were higher than those in the non-sleep disorder group(P<0.05).Logistic regression analysis showed that advanced age,left hemisphere cerebral infarction,high BMI,diabetes,coronary heart disease,high FSS score,high BDI score and high HAMA score were independent risk factors(P<0.05).Conclusion Advanced age,left hemisphere cerebral infarction,obesity,diabetes,coronary heart disease,fatigue,depression and anxiety can cause sleep disorders in MCI pat

关 键 词：脑梗死 轻度认知障碍 轻度 睡眠障碍 

分 类 号：R743.3[医药卫生—神经病学与精神病学]