Cleavable bimetallic-organic polymers for ROS mediated cascaded cancer therapy under the guidance of MRI through tumor hypoxia relief strategy  

作　　者：Haozhe He Lihua Du Min Tan Yali Chen Liejing Lu Yongcheng An Yong Wang Xiaoxia Li Bo Li Jun Shen Jun Wu Xintao Shuai 

机构地区：[1]PCFM Lab of Ministry of Education,School of Materials Science and Engineering,Sun Yat-Sen University,Guangzhou 510260,China [2]Department of Radiology,Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangzhou 510260,China [3]University of Laboratory of Interventional Radiology,Department of Minimally Invasive Interventional Radiology,and Department of Radiology,the Second Affiliated Hospital of Guangzhou Medical University,Guangzhou 510260,China [4]School of Biomedical Engineering,State Key Laboratory of Oncology in South China,Sun Yat-sen University,Guangzhou 510260,China

出　　处：《Science China Chemistry》2020年第7期936-945,共10页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China (51933011, 31971296, 21805314);the National Basic Research Program of China (2015CB755500);the Natural Science Foundation of the Guangdong Province (2014A030312018)。

摘　　要：Despite recent advances in tumor treatment, reactive oxygen species(ROS)-mediated therapy, such as photodynamic therapy(PDT) and chemical dynamic therapy(CDT), remains challenging mainly due to hypoxia in tumor microenviroment. Relieving the hypoxia of tumor tissue has been considered as an attractive strategy for enhancing efficacy of ROS-based cancer treatment.Herein, one cascaded platform was developed to overcome tumor hypoxia and synergistically enhance the effect of ROSmediated therapy. This platform is based on cleavable bimetallic metal organic polymers(DOX@Fe/Mn-THPPTK-PEG). As an efficient Fenton-like material, it could not only produce cytotoxic ·OH by catalyzing the decomposition of intracellular H2O2, but also generate O2 to alleviate tumor hypoxia. In addition, the DOX-loaded metal organic polymers(MOPs could be disrupted after being exposed to laser irradiation or/and treated with H2O2, and then release the DOX for chemotherapy. Overall, 3 therapies(hypoxia-relieved PDT, photo-enhanced CDT, and ROS-mediated chemotherapy) could be achieved simultaneously by such a smart platform. Furthermore, T1-weighted MRI imaging ability of the MOPs could be greatly improved under H2O2 treatment.Therefore, total four robust functions were realized in a simple platform. These findings demonstrate great clinical potentials of the MOPs for cancer theranostics.

关 键 词：reactive oxygen species photodynamic therapy chemodynamic therapy ROS sensitive drug releases MRI imaging 

分 类 号：R730.5[医药卫生—肿瘤] O634[医药卫生—临床医学]