2009—2018年北京地区单中心乳腺癌临床流行病学及病理特征回顾性分析  

A single center, retrospective analysis on clinical epidemiology and pathologic characteristics of breast cancer in Beijing from 2009 to 2018

作　　者：刘青[1] 张英[2] 周馨 吕灵艳 罗楚凡 王秀红[3] 刘军[4] 万冬桂[1] LIU Qing;ZHANG Ying;ZHOU Xin;LV Lingyan;LUO Chufan;WANG Xiuhong;LIU Jun;WAN Donggui(Department of Integrative Oncology,China-Japan Friendship Hospital,Beijing 100029,China;China-Japan Friendship Clinical Medical College,Beijing University of Chinese Medicine,Beijing 100029,China;Department of Pathology,China-Japan Friendship Hospital,Beijing 100029,China;Department of General Surgery,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]中日友好医院中西医结合肿瘤内科,北京100029 [2]北京中医药大学中日友好临床医学院,北京100029 [3]中日友好医院病理科,北京100029 [4]中日友好医院普通外科,北京100029

出　　处：《肿瘤》2020年第6期431-439,共9页Tumor

摘　　要：目的:分析对比2009—2018年中日友好医院收治的原发性乳腺癌患者的流行病学和临床病理学特征,以期为乳腺癌的防治工作提供临床参考依据。方法:收集2009年1月—2018年12月在中日友好医院首次确诊并接受住院治疗的初治原发性乳腺癌患者的临床及病理资料,回顾性分析确诊例数、年龄、病理类型、临床分期、分子分型、手术及临床特征,以及随年代的变化趋势。结果:共纳入2897例乳腺癌患者,女性2881例,其中处于绝经后状态的有1619例。近5年女性乳腺癌确诊病例数逐年递增,中位年龄为54.00岁,平均年龄为(54.56±12.55)岁,45~49岁为高发年龄段。浸润性导管癌是最主要的病理类型(占82.33%),分子分型以Luminal型为主(占76.46%),三阴性和人类表皮生长因子受体2(human epidermalgrowth factor receptor-2,HER-2)型次之;确诊时的疾病分期以0~Ⅱ期为主占83.65%,Ⅲ~Ⅳ期占16.35%。改良根治术是最主要的手术方式,保乳手术及前哨淋巴结活检在近年无明显增加。Logistic回归分析显示,三阴性乳腺癌以及Ki-67指数与确诊时疾病分期明显相关(P值均<0.05)。趋势检验结果提示,随着年份变化,确诊年龄和疾病分期均无显著变化趋势(P值均>0.05)。结论:近10年来中日友好医院单中心收治的乳腺癌患者确诊病例呈递增趋势,高发年龄段为45~49岁,早期患者占较大比例,Luminal型是最主要的分子亚型,三阴性以及Ki-67指数>14%是影响乳腺癌分期的危险因素,且疾病分期随时间的变化趋势不明显。Objective:To make a retrospective analysis on the clinical epidemiologic and pathologic characteristics of primary breast cancer patients in China-Japan Friendship Hospital from 2009 to 2018,in order to provide clinical evidence for the prevention and control of breast cancer.Methods:The clinical and pathological data of primary breast cancer patients who were firstly diagnosed and hospitalized in China-Japan Friendship Hospital from January 2009 to December 2018 were collected.The retrospective investigation and statistical analysis were performed based on the number of diagnosed cases,age distribution,pathological characterastics,clinical stage,molecular subtype and surgery type.Furthermore the trend of clinical features over time was analyzed.Results:A total of 2897 cases of breast cancer were recruited,1619 were postmenopausal in 2881 female patients.In the past five years,the number of diagnosed female cases increased year by year.The median age was 54.00 years old,the average age is(54.56±12.55)years old,with the peak in 45-49 years old.Invasive ductal carcinoma was the most common pathological type(82.33%),and the main molecular subtype was Luminal(76.46%),followed by triple-negative and human epidermal growth factor receptor-2(HER-2)types.The clinical stages at the time of diagnosis were mainly 0-Ⅱstages(83.65%).Modified radical mastectomy was a main surgery type,while the breast conserving operation and sentinel lymph node biopsy were not significantly improved in recent years.Logistic regression analysis showed that triple-negative subtype and Ki-67 index were signifitantly correlated with the disease staging of breast cancer at the time of diagnosis(both P<0.05).The trend test suggested that the diagnosed age and disease stage had not significantly changed with year(both P>0.05).Conclusion:In recent ten years,the number of female patients with breast cancer in China-Japan Friendship Hospital increased year by year.The peak onset age group was 45-49 years old,and the patients with early stage of brea

关 键 词：乳腺肿瘤 流行病学研究 病理学 临床 分子分型 

分 类 号：R737.9[医药卫生—肿瘤]