肿瘤内皮细胞标志物1在卵巢癌诊疗中作用的研究进展  

Research Progress in Tumor Endothelial Cell Marker 1 in Diagnosis and Treatment of Ovarian Cancer

作　　者：鲍会静 徐晨(审校)[2] BAO Hui-jing;XU Chen(Tianjin Nankai Hosptial,Tianjin 300100,China;Tianjin 4th Center Hospital,Tianjin 300140,China)

机构地区：[1]天津市南开医院,300100 [2]天津市第四中心医院

出　　处：《国际生殖健康／计划生育杂志》2020年第4期349-352,共4页Journal of International Reproductive Health/Family Planning

基　　金：天津市教委科研计划项目(2018KJ077)。

摘　　要：卵巢癌是一种常见的妇科恶性肿瘤,具有发病率高、致死率高的特点。由于其发病隐蔽且缺乏有效检测手段,确诊时一般已处于中晚期,因此提高卵巢癌早期诊断率可有效提高患者的预后及生存率。肿瘤内皮细胞标志物1(tumor endothelial marker 1,TEM1)是一种新近发现的卵巢癌特异性肿瘤标志物,其表达于卵巢癌细胞表面,而在正常组织中不表达或仅极低表达。该特点使TEM1成为极具潜能的卵巢癌诊断和治疗的新靶点。应用TEM1的特异性抗体结合影像学、基因工程学等技术,无论在卵巢癌影像以及治疗方面都显示出了极好的抗肿瘤效果。同时大量基于靶向TEM1的临床试验正在进行中。本文综述TEM1的发现、结构、组织表达以及其在卵巢癌诊断及治疗中的研究进展,以期为卵巢癌的治疗提供新思路。Ovarian cancer is a gynecological genital malignancy, with high incidence and high mortality.Because of the concealment of ovarian cancer and the lack of effective detection methods, the patients were found in the middle and late stage of the disease. Therefore, to improve the early diagnosis of ovarian cancer can effectively improve the prognosis and survival rate of patients. Tumor endothelial marker 1(TEM1) is a newlyfound tumor specific marker of ovarian cancer. TEM1 can be expressed on the surface of ovarian cancer cells, but not expressed or lowly expressed in normal tissues, suggesting that TEM1 is a potential target for the diagnosis and treatment of ovarian cancer. The specific antibody of TEM1 combined with imaging technology and genetic engineering technology has shown the excellent anti-tumor effect on ovarian cancer. At the same time, a large number of clinical trials based on the targeted TEM1 are being in progress. In this article, we review the discovery,structure and tissue expression of TEM1, and its research progress, in the diagnosis and treatment of ovarian cancer, in order to provide new ideas for the future treatment of ovarian cancer.

关 键 词：肿瘤内皮细胞标志物1 重组融合蛋白质类 抗原 肿瘤 卵巢肿瘤 诊断 治疗 

分 类 号：R737.31[医药卫生—肿瘤]