醒脑开窍针刺法对急性脑出血患者微创血肿清除术后神经功能、MMPS及Cysc的影响  

Effect of Xingnao Kaiqiao Acupuncture on Neurological Function,MMPS and Cysc in Patients with Acute Cerebral Hemorrhage

作　　者：苗志凯 王艳[1] 夏清岫[1] Miao Zhikai;Wang Yan;Xia Qingxiu(Cangzhou Hospital of Integrated TCM-WM,Hebei,Cangzhou 061000,China)

机构地区：[1]河北省沧州中西医结合医院,河北沧州061000

出　　处：《中国中医急症》2020年第7期1172-1175,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：河北省中医药管理局科研计划项目(2017143)。

摘　　要：目的观察醒脑开窍针刺法对急性脑出血患者微创血肿清除术后神经功能、基质金属蛋白酶(MMPS)及血清胱抑素C(Cysc)的影响。方法选择2018年3月至2019年2月在我院接受治疗的急性脑出血患者93例进行回顾性分析。根据患者接受治疗方式的不同将其分为两组,对照组行微创血肿清除术及常规西医术后管理;观察组则在对照组基础上加以醒脑开窍针刺法治疗。对比两组患者疗效、神经功能、肢体运动功能、日常活动能力、MMPS、Cysc及不良反应。结果观察组总有效率为82.98%,明显高于对照组的63.04%(P<0.05)。治疗后1个月两组患者美国国立卫生研究院卒中量表(NIHSS)得分均明显下降,但观察组下降幅度更大(P<0.05),治疗后1个月两组患者改良Barthel指数(MBI)及Fuel-Meyer(FMA)评分均明显升高,但观察组升高更明显(P<0.05)。治疗后两组患者MMP-2、MMP-9及Cysc均明显下降,但观察组下降幅度更大(P<0.05)。对照组出现4例(8.69%)不良反应,与观察组的3例(6.28%)差异无统计学意义(P> 0.05)。结论微创血肿清除术后应用醒脑开窍针刺法较常规术后治疗可明显提高急性脑出血患者疗效,改善神经功能、肢体运动功能、日常生活能力,降低MMPS及Cysc水平。Objective:To investigate the effect of Xingnao Kaiqiao acupuncture on neurological function,MMPS and Cysc in patients with acute cerebral hemorrhage. Methods:A retrospective analysis of 93 patients with acute cerebral hemorrhage treated in our hospital from March 2018 to February 2019 was performed. According to the different treatment methods,they were divided into two groups. The control group(46 cases)underwent minimally invasive hematoma evacuation and conventional Western medicine management;the observation group(47 cases)was treated with Xingnao Kaiqiao acupuncture on that basis. The efficacy,neurological function,limb motor function,daily activity,MMPS,Cysc and adverse reactions were compared between the two groups. Results:The total effective rate of the observation group was 82.98%,which was significantly higher than that of the control group(63.04%)(P< 0.05). 1 months after treatment,NIHSS scores of both groups decreased significantly,but the decrease of the observation group was larger(P< 0.05). MBI and FMA scores of both groups increased significantly,and the increase of the observation group was more significant(P< 0.05). After treatment,MMP-2,MMP-9 and Cysc decreased significantly in both groups,but the decrease was larger in the observation group(P< 0.05). There were 4 cases(8.69%)with adverse reactions in the control group,3 cases(6.28%)in the observation group. The difference was not statistically significant(P > 0.05). Conclusion:Xingnao Kaiqiao acupuncture can significantly improve the efficacy,neurological function,limb motor function and daily living ability,and reduce the levels of MMPS and Cysc in patients with acute cerebral hemorrhage.

关 键 词：急性脑出血 醒脑开窍针刺法 微创血肿清除术 神经功能 

分 类 号：R743.34[医药卫生—神经病学与精神病学]