溃疡性结肠炎患者血清钙水平与疾病关系研究  

Study on the relationship between serum calcium level and the disease in patients with ulcerative colitis

作　　者：张方 王丹丹[1] 耿丽 董月美 马娜[1] 冯百岁[1] ZHANG Fang;WANG Dandan;GENG Li;DONG Yuemei;MA Na;FENG Baisui(Department of Gastroenterology,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou University,Zhengzhou 450014,China)

机构地区：[1]郑州大学第二附属医院消化内科,河南郑州450014

出　　处：《胃肠病学和肝病学杂志》2020年第7期794-798,共5页Chinese Journal of Gastroenterology and Hepatology

基　　金：郑州大学前言交叉研究专项项目(32410243);河南省医学科技攻关计划省部共建项目(SBGJ2018042);河南省医学科技攻关计划联合共建项目(2018020164);河南省卫生计生科技创新型人才“51282”工程(豫卫科[2016]32号);河南省自然科学基金项目(162300410268)。

摘　　要：目的探究溃疡性结肠炎(ulcerative colitis, UC)患者血清钙水平变化及其与疾病的关系。方法选取2017年9月至2019年9月在郑州大学第二附属医院消化内科住院并确诊为UC的患者共38例,同时随机选取同期健康体检者38名作为正常对照组。收集患者入院后第一次空腹采血的血清总胆固醇、钙、磷、C反应蛋白及血沉数据进行分析比较。结果 UC患者血清总胆固醇、钙、磷水平均低于正常对照组(P<0.01)。不同严重程度患者血清钙水平差异有统计学意义(P<0.05)。血清钙与C反应蛋白及血沉呈负相关(P<0.05)。结论 UC患者血清总胆固醇、钙、磷水平均低于正常对照组,且与疾病严重程度呈负相关。Objective To investigate the changes of serum calcium level in patients with ulcerative colitis(UC) and its relationship with the disease. Methods A total of 38 patients who were admitted to the Department of Gastroenterology of the Second Affiliated Hospital of Zhengzhou University from Sep. 2017 to Sep. 2019 and diagnosed with UC were selected. At the same time, 38 cases of healthy people who were examined during the same period were randomly selected as the normal control group. The serum total cholesterol, calcium, phosphorus, C-reactive protein and erythrocyte sedimentation data were collected for the first fasting blood collection after admission to the hospital for analysis and comparison. Results Serum total cholesterol, calcium, and phosphorus levels in patients with UC were lower than those in the control group(P<0.01). Serum calcium levels were different in patients with different severity(P<0.05). Serum calcium was negatively correlated with C-reactive protein and erythrocyte sedimentation(P<0.05). Conclusion Serum total cholesterol, calcium, and phosphorus levels of patients with UC are lower than those of the normal control group, and are negatively related to the severity of the disease.

关 键 词：溃疡性结肠炎 血清钙 胆固醇 维生素D 代谢性骨病 炎症性肠病 

分 类 号：R574.1[医药卫生—消化系统]